Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | KCNJ1 | P48048 | 4/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.44 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 4/20 | 0.43 |
| ▸ | CA2 | P00918 | 4/20 | 0.43 |
| ▸ | CA12 | O43570 | 3/20 | 0.43 |
| ▸ | CA4 | P22748 | 2/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 2/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | CA3 | P07451 | 1/20 | 0.40 |
| ▸ | CA6 | P23280 | 1/20 | 0.40 |
| ▸ | CA5A | P35218 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2233530 | 0.92 | TSHR (0.56) | TSHRKCNJ1KCNH2LOXL2CA1 | |
| SCHEMBL77658 | 0.85 | TSHR (0.64) | TSHRKCNJ1KCNH2LOXL2HRH3 | |
| SCHEMBL28531315 | 0.78 | TSHR (0.60) | TSHRKCNJ1KCNH2LOXL2CA1 | |
| SCHEMBL9259965 | 0.75 | TSHR (0.56) | TSHRKCNJ1KCNH2LOXL2CA1 | |
| SCHEMBL31540565 | 0.75 | TSHR (0.56) | TSHRKCNJ1KCNH2LOXL2CA1 | |
| SCHEMBL8898338 | 0.75 | TSHR (0.56) | TSHRKCNJ1KCNH2LOXL2CA1 | |
| SCHEMBL291237 | 0.75 | TSHR (0.61) | TSHRKCNJ1KCNH2LOXL2CA1 | |
| SCHEMBL1425484 | 0.74 | LOXL2 (0.53) | TSHRLOXL2CA1CA2CA12 | |
| SCHEMBL1169852 | 0.74 | TSHR (0.60) | TSHRKCNJ1KCNH2LOXL2HRH3 | |
| SCHEMBL879695 | 0.73 | TSHR (0.60) | TSHRCA2CYP1A2CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1937681-A1 | 5-OXO-5,8-DIHYDRO-PYRIDO-PYRIMIDINES AS INHIBITORS OF C-FMS KINASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-07-02 | — | — | EP | disclosed |
| WO-2007033232-A1 | 5-OXO-5,8-DIHYDRO-PYRIDO-PYRIMIDINES AS INHIBITORS OF C-FMS KINASE | JANSSEN PHARMACEUTICA, N.V. (BE) | 2007-03-22 | — | — | WO | disclosed |