Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.46 |
| ▸ | GPR183 | P32249 | 1/20 | 0.46 |
| ▸ | GABBR2 | O75899 | 4/20 | 0.37 |
| ▸ | GABBR1 | Q9UBS5 | 4/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.35 |
| ▸ | HRH2 | P25021 | 1/20 | 0.35 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.33 |
| ▸ | RET | P07949 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13177946 | 0.85 | TTK (0.35) | ADORA3ADORA1 | |
| SCHEMBL4769111 | 0.81 | TTK (0.41) | ADORA1 | |
| SCHEMBL4769217 | 0.81 | TTK (0.36) | RET | |
| SCHEMBL10171936 | 0.78 | ADORA3 (0.55) | ADORA3ADORA1ADORA2AGPR183 | |
| SCHEMBL10171219 | 0.75 | ADORA3 (0.57) | ADORA3ADORA1ADORA2AGPR183GABBR2 | |
| SCHEMBL10171965 | 0.74 | ADORA3 (0.52) | ADORA3ADORA1ADORA2AGPR183GABBR2 | |
| SCHEMBL3706266 | 0.74 | ADORA3 (0.59) | ADORA3ADORA1ADORA2AGPR183 | |
| SCHEMBL10171497 | 0.72 | ADORA3 (0.52) | ADORA3ADORA1ADORA2AGPR183JAK2 | |
| SCHEMBL10171297 | 0.72 | ADORA3 (0.53) | ADORA3ADORA1ADORA2AGPR183GABBR2 | |
| SCHEMBL10171934 | 0.72 | ADORA3 (0.64) | ADORA3ADORA1ADORA2AGPR183JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120122840-A1 | COMPOUNDS AND THERAPEUTIC USES THEREOF | MYREXIS, INC. (US) | 2012-05-17 | — | — | US | disclosed |
| US-20120122840-A1 | COMPOUNDS AND THERAPEUTIC USES THEREOF | MYREXIS, INC. (US) | 2012-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120122840-A1 | COMPOUNDS AND THERAPEUTIC USES THEREOF | VHL, TP53, ASAH2 | ADORA3 1744/4885ADORA1 2771/4885ADORA2A 1259/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.