Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | PDE5A | O76074 | 8/20 | 0.39 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4762021 | 0.92 | PDE5A (0.40) | PDE5AENPP2 | |
| SCHEMBL5359565 | 0.90 | KDM4E (0.46) | PDE5AENPP2 | |
| SCHEMBL4762032 | 0.88 | SMN1; SMN2 (0.41) | PDE5AENPP2 | |
| SCHEMBL4762020 | 0.87 | PDE5A (0.47) | PDE5AENPP2 | |
| SCHEMBL4771130 | 0.82 | PDE5A (0.43) | PDE5A | |
| SCHEMBL4762016 | 0.81 | PDE5A (0.37) | PDE5A | |
| SCHEMBL4763460 | 0.80 | KDM4E (0.41) | THRB | |
| SCHEMBL5371025 | 0.77 | PDE5A (0.41) | PDE5A | |
| SCHEMBL4769335 | 0.77 | PDE5A (0.41) | PDE5A | |
| SCHEMBL7011555 | 0.76 | PDE5A (0.44) | PDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1432715-B1 | PYRIMIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2008-03-19 | — | — | EP | disclosed |