Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4762182 | 0.84 | ALDH1A1 (0.44) | KDM4EALDH1A1KMT2AMEN1HTT | |
| SCHEMBL4769340 | 0.80 | THRB (0.40) | THRB | |
| SCHEMBL4764889 | 0.80 | ACACA (0.37) | KDM4EALDH1A1KMT2ATHRBGAA | |
| SCHEMBL1368664 | 0.66 | KDM4E (0.37) | KDM4EALDH1A1KMT2AMEN1LMNA | |
| SCHEMBL6953942 | 0.65 | BCHE (0.61) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL8552607 | 0.63 | BCHE (0.35) | ALDH1A1KMT2AGAATP53LMNA | |
| SCHEMBL4640870 | 0.61 | — | — | |
| SCHEMBL1078049 | 0.61 | ALDH1A1 (0.57) | ALDH1A1GAALMNAHTTMAPT | |
| SCHEMBL9330353 | 0.60 | SCN1A (0.49) | ALDH1A1KMT2AMEN1SMN1; SMN2MAPT | |
| SCHEMBL8534997 | 0.60 | TP53 (0.37) | ALDH1A1KMT2ATHRBGAAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1432715-B1 | PYRIMIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2008-03-19 | — | — | EP | disclosed |