Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERBB2 | P04626 | 10/20 | 0.70 |
| ▸ | HDAC3 | O15379 | 9/20 | 0.70 |
| ▸ | HDAC4 | P56524 | 9/20 | 0.70 |
| ▸ | HDAC1 | Q13547 | 9/20 | 0.70 |
| ▸ | HDAC7 | Q8WUI4 | 9/20 | 0.70 |
| ▸ | HDAC2 | Q92769 | 9/20 | 0.70 |
| ▸ | HDAC10 | Q969S8 | 9/20 | 0.70 |
| ▸ | HDAC11 | Q96DB2 | 9/20 | 0.70 |
| ▸ | HDAC8 | Q9BY41 | 9/20 | 0.70 |
| ▸ | HDAC6 | Q9UBN7 | 9/20 | 0.70 |
| ▸ | HDAC9 | Q9UKV0 | 9/20 | 0.70 |
| ▸ | HDAC5 | Q9UQL6 | 9/20 | 0.70 |
| ▸ | EGFR | P00533 | 9/20 | 0.70 |
| ▸ | KDR | P35968 | 13/20 | 0.65 |
| ▸ | CSF1R | P07333 | 1/20 | 0.65 |
| ▸ | STK10 | O94804 | 1/20 | 0.64 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.64 |
| ▸ | ABL1 | P00519 | 1/20 | 0.64 |
| ▸ | YES1 | P07947 | 1/20 | 0.64 |
| ▸ | RET | P07949 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4769163 | 0.99 | ERBB2 (0.69) | ERBB2HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL4766427 | 0.94 | KDR (0.75) | ERBB2HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL27585231 | 0.94 | KDR (0.68) | ERBB2HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL27585234 | 0.94 | KDR (0.75) | ERBB2HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL4769383 | 0.94 | KDR (0.68) | ERBB2HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL4764167 | 0.93 | ERBB2 (0.67) | ERBB2HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL4765896 | 0.91 | KDR (0.74) | ERBB2HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL4768455 | 0.86 | KDR (0.74) | ERBB2HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL6712869 | 0.86 | KDR (0.74) | ERBB2HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL4791793 | 0.86 | KDR (0.60) | ERBB2HDAC3HDAC4HDAC1HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1416935-B1 | 4-AMINO-6-PHENYL-PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES | NOVARTIS AG (CH) | 2008-03-12 | — | — | EP | claimed |
| US-7244729-B2 | 4-amino-6-phenyl-pyrrolo[2,3-d]pyrimidine derivatives | NOVARTIS AG (CH) | 2007-07-17 | — | — | US | claimed |
| US-20040248911-A1 | 7H-pyrrolo[2,3-d]pyrimidine derivatives | BOLD GUIDO (CH) | 2004-12-09 | — | — | US | claimed |
| EP-1416935-B1 | 4-AMINO-6-PHENYL-PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES | NOVARTIS AG (CH) | 2008-03-12 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040248911-A1 | 7H-pyrrolo[2,3-d]pyrimidine derivatives | DPYD, DHPS, TYMP | ERBB2 2012/4885HDAC3 3290/4885HDAC4 3865/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.