Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 4/20 | 0.57 |
| ▸ | EDNRB | P24530 | 3/20 | 0.57 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4769412 | 0.98 | EDNRA (0.57) | EDNRAEDNRBAGTR1 | |
| SCHEMBL4766190 | 0.95 | EDNRA (0.59) | EDNRAEDNRB | |
| SCHEMBL4793393 | 0.94 | EDNRA (0.55) | EDNRAEDNRBAGTR1 | |
| SCHEMBL4776135 | 0.92 | EDNRB (0.60) | EDNRAEDNRB | |
| SCHEMBL5521701 | 0.91 | EDNRA (0.57) | EDNRAEDNRBAGTR1 | |
| SCHEMBL4767169 | 0.91 | EDNRB (0.57) | EDNRAEDNRB | |
| SCHEMBL4764814 | 0.90 | EDNRB (0.64) | EDNRAEDNRB | |
| SCHEMBL4792865 | 0.90 | EDNRA (0.57) | EDNRAEDNRBAGTR1 | |
| SCHEMBL6940694 | 0.90 | EDNRA (0.55) | EDNRAEDNRBAGTR1 | |
| SCHEMBL4771034 | 0.90 | EDNRA (0.57) | EDNRAEDNRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2002837-A1 | Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-12-17 | — | — | EP | claimed |
| EP-2002837-A1 | Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-12-17 | — | — | EP | disclosed |
| EP-1741713-A2 | Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists | Bristol-Myers Squibb Company (US) | 2007-01-10 | — | — | EP | disclosed |
| EP-1237888-B1 | BIPHENYL SULFONAMIDES AS DUAL ANGIOTENSIN ENDOTHELIN RECEPTOR ANTAGONISTS | BRISTOL MYERS SQUIBB CO (US) | 2006-09-13 | — | — | EP | disclosed |
| US-6638937-B2 | As antihypertensive agents; for therapy of disorders related to renal, glomerular and mesangial cell function; therapy of endotoxemia or endotoxin shock as well as hemorrhagic shock; useful in alleviation of pain associated cancer | BRISTOL-MYERS SQUIBB CO. | 2003-10-28 | — | — | US | disclosed |