Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 5/20 | 0.55 |
| ▸ | EDNRB | P24530 | 2/20 | 0.55 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5521701 | 0.94 | EDNRA (0.57) | EDNRAEDNRBAGTR1 | |
| SCHEMBL4769412 | 0.91 | EDNRA (0.57) | EDNRAEDNRBAGTR1 | |
| SCHEMBL4769585 | 0.90 | EDNRA (0.53) | EDNRAEDNRBAGTR1 | |
| SCHEMBL6483932 | 0.90 | EDNRA (0.53) | EDNRAEDNRBAGTR1 | |
| SCHEMBL4769447 | 0.90 | EDNRA (0.57) | EDNRAEDNRBAGTR1 | |
| SCHEMBL5536203 | 0.90 | EDNRA (0.59) | EDNRAEDNRB | |
| SCHEMBL5528858 | 0.89 | EDNRA (0.54) | EDNRAEDNRBAGTR1 | |
| SCHEMBL4773576 | 0.88 | EDNRA (0.55) | EDNRAEDNRBAGTR1 | |
| SCHEMBL4771908 | 0.88 | EDNRA (0.57) | EDNRAEDNRBAGTR1 | |
| SCHEMBL5789581 | 0.88 | EDNRA (0.56) | EDNRAEDNRBAGTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6638937-B2 | As antihypertensive agents; for therapy of disorders related to renal, glomerular and mesangial cell function; therapy of endotoxemia or endotoxin shock as well as hemorrhagic shock; useful in alleviation of pain associated cancer | BRISTOL-MYERS SQUIBB CO. | 2003-10-28 | — | — | US | disclosed |