Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 4/20 | 0.55 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.55 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | ESR1 | P03372 | 1/20 | 0.46 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1640287 | 0.96 | LTA4H (0.59) | LTA4HPTGS2PTGS1ALDH1A1KDM4E | |
| SCHEMBL3441632 | 0.95 | LTA4H (0.57) | LTA4HPTGS2PTGS1ALDH1A1KDM4E | |
| SCHEMBL4773803 | 0.90 | LTA4H (0.52) | LTA4HPTGS2PTGS1ALDH1A1KDM4E | |
| SCHEMBL2717838 | 0.85 | CYP1A2 (0.52) | ALDH1A1KDM4ES1PR4MEN1KMT2A | |
| SCHEMBL15567163 | 0.82 | LTA4H (0.60) | LTA4HPTGS2PTGS1ALDH1A1KDM4E | |
| SCHEMBL24398580 | 0.81 | LTA4H (0.59) | LTA4HPTGS2PTGS1ALDH1A1KDM4E | |
| SCHEMBL1641697 | 0.81 | LTA4H (0.59) | LTA4HPTGS2PTGS1ALDH1A1KDM4E | |
| SCHEMBL14453651 | 0.81 | SMN1; SMN2 (0.63) | LTA4HPTGS2PTGS1ALDH1A1KDM4E | |
| SCHEMBL14453652 | 0.81 | LTA4H (0.55) | LTA4HPTGS2PTGS1ALDH1A1KDM4E | |
| SCHEMBL30950899 | 0.81 | LTA4H (0.55) | LTA4HPTGS2PTGS1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1987042-A2 | NOVEL AMINO ALCOHOL-SUBSTITUTED ARYLTHIENOPYRIMIDINONES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS | sanofi-aventis (FR) | 2008-11-05 | — | — | EP | disclosed |
| WO-2007093365-A2 | NOVEL AMINO ALCOHOL-SUBSTITUTED ARYLTHIENOPYRIMIDINONES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS | SANOFI-AVENTIS (DE) | 2007-08-23 | — | — | WO | disclosed |