Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.40 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.40 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4772301 | 0.89 | SMN1; SMN2 (0.39) | NPC1RAB9APDE4BKDM4EMAPT | |
| SCHEMBL4772312 | 0.89 | SMN1; SMN2 (0.39) | NPC1RAB9APDE4BKDM4EMAPT | |
| SCHEMBL4776153 | 0.81 | TBXAS1 (0.40) | NPC1RAB9AKDM4EMAPTCYP1A2 | |
| SCHEMBL4776157 | 0.81 | TBXAS1 (0.40) | NPC1RAB9AKDM4EMAPTCYP1A2 | |
| SCHEMBL4774023 | 0.81 | MAPT (0.56) | NPC1RAB9APDE4BKDM4EMAPT | |
| SCHEMBL1814100 | 0.81 | HPGD (0.36) | NPC1RAB9APDE4BKDM4EMAPT | |
| SCHEMBL1814098 | 0.81 | HPGD (0.36) | NPC1RAB9APDE4BKDM4EMAPT | |
| SCHEMBL4772590 | 0.81 | KDM4E (0.41) | NPC1RAB9APDE4BKDM4EMAPT | |
| SCHEMBL4776341 | 0.79 | HPGD (0.35) | NPC1RAB9APDE4BKDM4EMAPT | |
| SCHEMBL4776350 | 0.79 | HPGD (0.35) | NPC1RAB9APDE4BKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1763528-B1 | PYRAZOLOPYRIDINE DERIVATIVES | ASTELLAS PHARMA INC (JP) | 2008-11-26 | — | — | EP | claimed |