Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 18/20 | 0.52 |
| ▸ | ADORA1 | P30542 | 14/20 | 0.52 |
| ▸ | ADORA2A | P29274 | 11/20 | 0.52 |
| ▸ | ADORA3 | P0DMS8 | 5/20 | 0.40 |
| ▸ | PLK4 | O00444 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.37 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.37 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.37 |
| ▸ | CSNK1G3 | Q9Y6M4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4769673 | 1.00 | ADORA2B (0.52) | ADORA2BADORA1ADORA2AADORA3PLK4 | |
| SCHEMBL4767719 | 0.95 | ADORA2B (0.45) | ADORA2BADORA1ADORA2AADORA3 | |
| SCHEMBL4767733 | 0.95 | ADORA2B (0.45) | ADORA2BADORA1ADORA2AADORA3 | |
| SCHEMBL4770754 | 0.92 | ADORA2B (0.48) | ADORA2BADORA1ADORA2AADORA3 | |
| SCHEMBL4770747 | 0.92 | ADORA2B (0.48) | ADORA2BADORA1ADORA2AADORA3 | |
| SCHEMBL4766139 | 0.91 | ADORA2B (0.49) | ADORA2BADORA1ADORA2AADORA3 | |
| SCHEMBL4769328 | 0.90 | ADORA2B (0.49) | ADORA2BADORA1ADORA2AADORA3 | |
| SCHEMBL4769321 | 0.90 | ADORA2B (0.49) | ADORA2BADORA1ADORA2AADORA3 | |
| SCHEMBL4763384 | 0.88 | ADORA2B (0.44) | ADORA2BADORA1ADORA2AADORA3 | |
| SCHEMBL4766145 | 0.88 | ADORA2B (0.41) | ADORA2BADORA1ADORA2AADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678181-B1 | A2B ADENOSINE RECEPTOR ANTAGONISTS | CV THERAPEUTICS INC (US) | 2008-12-31 | — | — | EP | disclosed |