Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | BRAF | P15056 | 4/20 | 0.46 |
| ▸ | KDR | P35968 | 3/20 | 0.46 |
| ▸ | DAPK1 | P53355 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | RAF1 | P04049 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1927233 | 0.88 | CSF1R (0.55) | CSF1RLMNAMAPTBRAFKDR | |
| SCHEMBL7645864 | 0.82 | MAPT (0.55) | CSF1RLMNAMAPTALDH1A1MEN1 | |
| SCHEMBL27836763 | 0.80 | EPHX2 (0.56) | BRAFALDH1A1 | |
| SCHEMBL16620552 | 0.79 | MAPT (0.63) | LMNAMAPTALDH1A1AKR1C3MEN1 | |
| SCHEMBL16907437 | 0.79 | GAA (0.58) | CSF1RMAPTBRAFKDRALDH1A1 | |
| SCHEMBL7645869 | 0.79 | CSF1R (0.48) | CSF1RLMNAMAPTBRAFKDR | |
| SCHEMBL7645874 | 0.78 | MAPT (0.47) | CSF1RLMNAMAPTBRAFKDR | |
| SCHEMBL1420146 | 0.77 | CSF1R (0.60) | CSF1RLMNAMAPTBRAFALDH1A1 | |
| SCHEMBL30087055 | 0.77 | TMPRSS4 (0.68) | CSF1RKDRMEN1KMT2A | |
| SCHEMBL28916400 | 0.77 | TMPRSS4 (0.68) | CSF1RKDRMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904498-A1 | FUSED HETEROCYCLIC DERIVATIVES AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2008-04-02 | — | — | EP | disclosed |
| WO-2007004749-A1 | FUSED HETEROCYCLIC DERIVATIVES AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-01-11 | — | — | WO | disclosed |