SCHEMBL4769822

SCHEMBL4769822

CCON(C(=O)C(C)(N)CO)c1ccccc1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 4/20 0.44
SMN1; SMN2 Q16637 3/20 0.44
MEN1 O00255 3/20 0.44
CYP2C9 P11712 2/20 0.44
CYP2C19 P33261 2/20 0.44
CYP3A4 P08684 1/20 0.44
ALDH1A1 P00352 7/20 0.37
TSHR P16473 2/20 0.37
GLA P06280 1/20 0.37
TP53 P04637 1/20 0.36
PIN1 Q13526 1/20 0.35
CYP1A2 P05177 1/20 0.35
MAPT P10636 1/20 0.35
HPGD P15428 1/20 0.35
HSD17B10 Q99714 1/20 0.35
NPSR1 Q6W5P4 2/20 0.34
RIPK1 Q13546 2/20 0.34
MMP8 P22894 1/20 0.34
L3MBTL1 Q9Y468 1/20 0.34
MMP1 P03956 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5510643 0.76 ALDH1A1 (0.44) KMT2ASMN1; SMN2MEN1CYP2C9CYP2C19
SCHEMBL25336401 0.76 ALDH1A1 (0.47) KMT2ASMN1; SMN2MEN1ALDH1A1TSHR
SCHEMBL5512049 0.76 ALDH1A1 (0.47) KMT2ASMN1; SMN2MEN1ALDH1A1TSHR
SCHEMBL13603966 0.74 ALDH1A1 (0.46) KMT2ASMN1; SMN2MEN1CYP2C9CYP2C19
SCHEMBL5932403 0.74 ALDH1A1 (0.46) KMT2ASMN1; SMN2MEN1CYP2C9CYP2C19
SCHEMBL29024419 0.74 TP53 (0.42) KMT2ASMN1; SMN2MEN1CYP2C9CYP2C19
SCHEMBL13603962 0.73 TP53 (0.61) KMT2ASMN1; SMN2MEN1ALDH1A1TSHR
SCHEMBL5932829 0.73 ALDH1A1 (0.44) KMT2ASMN1; SMN2MEN1CYP2C9CYP2C19
SCHEMBL5932823 0.73 ALDH1A1 (0.44) KMT2ASMN1; SMN2MEN1CYP2C9CYP2C19
SCHEMBL8392178 0.73 ALDH1A1 (0.44) KMT2ASMN1; SMN2MEN1CYP2C9CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1981837-A2 METHODS AND COMPOSITIONS FOR MODULATING SPHINGOSINE-1-PHOSPHATE (S1P) RECEPTOR ACTIVITY Praecis Pharmaceuticals Incorporated (US) 2008-10-22 EP disclosed
WO-2007092190-A2 METHODS AND COMPOSITIONS FOR MODULATING SPHINGOSINE-1-PHOSPHATE (S1P) RECEPTOR ACTIVITY PRAECIS PHARMACEUTICALS, INC. (US) 2007-08-16 WO disclosed