Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MALT1 | Q9UDY8 | 5/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.46 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4769848 | 1.00 | MALT1 (0.50) | MALT1SMN1; SMN2GAAALDH1A1MAPT | |
| SCHEMBL4764237 | 0.89 | ALDH1A1 (0.49) | ALDH1A1MAPTMEN1KMT2ANPC1 | |
| SCHEMBL4764235 | 0.89 | ALDH1A1 (0.49) | ALDH1A1MAPTMEN1KMT2ANPC1 | |
| SCHEMBL330988 | 0.86 | ALDH1A1 (0.49) | MALT1GAAALDH1A1MAPTMEN1 | |
| SCHEMBL330987 | 0.86 | ALDH1A1 (0.49) | MALT1GAAALDH1A1MAPTMEN1 | |
| SCHEMBL30968029 | 0.83 | MEN1 (0.46) | SMN1; SMN2ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL4790229 | 0.82 | ALDH1A1 (0.65) | ALDH1A1MAPTMEN1KMT2ANPC1 | |
| SCHEMBL4790228 | 0.82 | ALDH1A1 (0.65) | ALDH1A1MAPTMEN1KMT2ANPC1 | |
| SCHEMBL329897 | 0.80 | ALDH1A1 (0.59) | MALT1SMN1; SMN2GAAALDH1A1MAPT | |
| SCHEMBL329898 | 0.80 | ALDH1A1 (0.59) | MALT1SMN1; SMN2GAAALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1881975-A1 | N,N-SUBSTITUTED 3-AMINOPYRROLIDINE COMPOUNDS USEFUL AS MONOAMINES REUPTAKE INHIBITORS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2008-01-30 | — | — | EP | disclosed |
| WO-2006121218-A1 | N,N-SUBSTITUTED 3-AMINOPYRROLIDINE COMPOUNDS USEFUL AS MONOAMINES REUPTAKE INHIBITORS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2006-11-16 | — | — | WO | disclosed |