Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK9 | P45984 | 1/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 2/20 | 0.43 |
| ▸ | MAOB | P27338 | 2/20 | 0.43 |
| ▸ | CNR2 | P34972 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | CASP1 | P29466 | 2/20 | 0.41 |
| ▸ | CASP7 | P55210 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | GSK3A | P49840 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | KCNH3 | Q9ULD8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4770076 | 0.93 | MAPK9 (0.45) | MAPK9MAPK10MAOAMAOBCNR2 | |
| SCHEMBL4764815 | 0.89 | CHEK1 (0.49) | MAPK9MAPK10MAOAMAOBCNR2 | |
| SCHEMBL4767501 | 0.84 | SMN1; SMN2 (0.42) | MAPK9MAPK10ALDH1A1MEN1KMT2A | |
| SCHEMBL4767407 | 0.84 | CHEK1 (0.43) | MAPK9MAPK10MAOAMAOBCNR2 | |
| SCHEMBL4764898 | 0.83 | ESR1 (0.42) | CNR2ALDH1A1MEN1KMT2A | |
| SCHEMBL4766654 | 0.82 | CHEK1 (0.46) | MAPK9MAPK10CHEK1NTRK2HDAC1 | |
| SCHEMBL4770029 | 0.82 | SYK (0.44) | MAPK9MAPK10MAOAMAOBCNR2 | |
| SCHEMBL4774864 | 0.82 | CHEK1 (0.50) | MAPK9MAPK10CNR2CYP1A2CYP3A4 | |
| SCHEMBL4769925 | 0.81 | AURKA (0.48) | MAPK9NTRK2GSK3AGSK3BCDK1 | |
| SCHEMBL4765299 | 0.80 | SYK (0.49) | MAPK9CHEK1NTRK2HDAC1CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1581531-B1 | PYRIDINO¬2,3-D PYRIMIDINE DERIVATIVES AS SELECTIIVE KDR AND FGFR INHIBITORS | HOFFMANN LA ROCHE (CH) | 2008-02-27 | — | — | EP | claimed |
| US-7098332-B2 | 5,8-Dihydro-6H-pyrido[2,3-d]pyrimidin-7-ones | HOFFMANN-LA ROCHE INC. (US) | 2006-08-29 | — | — | US | claimed |
| EP-1581531-A1 | PYRIDINO[2,3-D]PYRIMIDINE DERIVATIVES AS SELECTIIVE KDR AND FGFR INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2005-10-05 | — | — | EP | claimed |
| WO-2004056822-A1 | PYRIDINO `2, 3-D! PYRIMIDINE DERIVATIVES AS SELECTIVE KDR AND FGFR INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2004-07-08 | — | — | WO | claimed |
| US-20040122029-A1 | Novel dihydropyridinone compounds | LIU JIN-JUN (US) | 2004-06-24 | — | — | US | claimed |
| EP-1581531-B1 | PYRIDINO¬2,3-D PYRIMIDINE DERIVATIVES AS SELECTIIVE KDR AND FGFR INHIBITORS | HOFFMANN LA ROCHE (CH) | 2008-02-27 | — | — | EP | disclosed |
| EP-1581531-B1 | PYRIDINO¬2,3-D PYRIMIDINE DERIVATIVES AS SELECTIIVE KDR AND FGFR INHIBITORS | HOFFMANN LA ROCHE (CH) | 2008-02-27 | — | — | EP | disclosed |
| US-7098332-B2 | 5,8-Dihydro-6H-pyrido[2,3-d]pyrimidin-7-ones | HOFFMANN-LA ROCHE INC. (US) | 2006-08-29 | — | — | US | disclosed |
| EP-1581531-A1 | PYRIDINO[2,3-D]PYRIMIDINE DERIVATIVES AS SELECTIIVE KDR AND FGFR INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2005-10-05 | — | — | EP | disclosed |
| WO-2004056822-A1 | PYRIDINO `2, 3-D! PYRIMIDINE DERIVATIVES AS SELECTIVE KDR AND FGFR INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2004-07-08 | — | — | WO | disclosed |
| US-20040122029-A1 | Novel dihydropyridinone compounds | LIU JIN-JUN (US) | 2004-06-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040122029-A1 | Novel dihydropyridinone compounds | FGFR1, FGFR3, FGFR4 | MAPK9 536/4885MAPK10 1141/4885MAOA 3592/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.