Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK9 | P45984 | 1/20 | 0.45 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.45 |
| ▸ | CNR2 | P34972 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | CASP1 | P29466 | 2/20 | 0.42 |
| ▸ | CASP7 | P55210 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 2/20 | 0.41 |
| ▸ | MAOB | P27338 | 2/20 | 0.41 |
| ▸ | CCKAR | P32238 | 3/20 | 0.41 |
| ▸ | GSK3A | P49840 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4769944 | 0.93 | MAPK9 (0.44) | MAPK9MAPK10CNR2CYP1A2CYP3A4 | |
| SCHEMBL4774864 | 0.89 | CHEK1 (0.50) | MAPK9MAPK10CNR2CYP1A2CYP3A4 | |
| SCHEMBL4775312 | 0.84 | GAA (0.43) | MAPK9MAPK10ALDH1A1MEN1KMT2A | |
| SCHEMBL4765275 | 0.84 | CHEK1 (0.43) | MAPK9MAPK10CNR2CYP1A2CYP3A4 | |
| SCHEMBL4764854 | 0.82 | CCKAR (0.45) | CYP1A2TSHRCCKAR | |
| SCHEMBL4771624 | 0.82 | CHEK1 (0.46) | MAPK9MAPK10CHEK1NTRK2HDAC1 | |
| SCHEMBL4764815 | 0.82 | CHEK1 (0.49) | MAPK9MAPK10CNR2CHEK1NTRK2 | |
| SCHEMBL4765277 | 0.81 | SYK (0.44) | MAPK9MAPK10CHEK1NTRK2MAOA | |
| SCHEMBL4766694 | 0.80 | SYK (0.50) | MAPK9CHEK1NTRK2HDAC1CDK4 | |
| SCHEMBL4767407 | 0.77 | CHEK1 (0.43) | MAPK9MAPK10CNR2CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1581531-B1 | PYRIDINO¬2,3-D PYRIMIDINE DERIVATIVES AS SELECTIIVE KDR AND FGFR INHIBITORS | HOFFMANN LA ROCHE (CH) | 2008-02-27 | — | — | EP | claimed |