Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 16/20 | 0.51 |
| ▸ | CTSL | P07711 | 13/20 | 0.51 |
| ▸ | CTSS | P25774 | 11/20 | 0.51 |
| ▸ | CTSB | P07858 | 6/20 | 0.51 |
| ▸ | CTSV | O60911 | 2/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4770612 | 0.95 | CTSK (0.51) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL4763068 | 0.92 | CTSK (0.54) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL14345775 | 0.92 | CTSK (0.54) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL6843794 | 0.89 | CTSK (0.51) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL6601173 | 0.88 | CTSK (0.55) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL4770083 | 0.88 | CTSK (0.50) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL4763047 | 0.86 | CTSK (0.53) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL4792835 | 0.85 | CTSK (0.56) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL4686496 | 0.81 | CTSK (0.49) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL5099174 | 0.81 | CTSK (0.57) | CTSKCTSLCTSSCTSBCTSV |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1320370-A4 | METHOD OF TREATMENT | SMITHKLINE BEECHAM CORP (US) | 2008-10-22 | — | — | EP | disclosed |
| EP-1320370-A1 | METHOD OF TREATMENT | SmithKline Beecham Corporation (US) | 2003-06-25 | — | — | EP | disclosed |
| WO-2002017924-A1 | METHOD OF TREATMENT | SMITHKLINE BEECHAM CORPORATION (GB) | 2002-03-07 | — | — | WO | disclosed |