Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 11/20 | 0.46 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 4/20 | 0.43 |
| ▸ | BRDT | Q58F21 | 4/20 | 0.43 |
| ▸ | JAK1 | P23458 | 3/20 | 0.43 |
| ▸ | JAK3 | P52333 | 2/20 | 0.43 |
| ▸ | BRD2 | P25440 | 2/20 | 0.43 |
| ▸ | BRD3 | Q15059 | 2/20 | 0.43 |
| ▸ | CDK2 | P24941 | 4/20 | 0.41 |
| ▸ | CDK1 | P06493 | 2/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.40 |
| ▸ | AURKA | O14965 | 2/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.40 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4882421 | 0.86 | USP30 (0.47) | JAK2JAK1NPC1RAB9A | |
| SCHEMBL4772447 | 0.86 | NPC1 (0.44) | BRD4PDE4APDE4BPDE4DJAK2 | |
| SCHEMBL4879890 | 0.84 | PDE4B (0.49) | BRD4PDE4APDE4BPDE4DAURKA | |
| SCHEMBL4879896 | 0.84 | PDE4B (0.49) | BRD4PDE4APDE4BPDE4DAURKA | |
| SCHEMBL4872296 | 0.83 | NPC1 (0.40) | BRD4PDE4APDE4BPDE4DJAK2 | |
| SCHEMBL4879863 | 0.83 | NPC1 (0.40) | BRD4PDE4APDE4BPDE4DJAK2 | |
| SCHEMBL4770418 | 0.73 | DHODH (0.49) | AURKAAURKBNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3695837 | 0.70 | SYK (0.41) | PDE4APDE4BPDE4DJAK2JAK1 | |
| SCHEMBL871576 | 0.70 | SYK (0.41) | PDE4APDE4BPDE4DJAK2JAK1 | |
| SCHEMBL8177429 | 0.69 | SCN9A (0.42) | JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1922318-A1 | PYRIDOPYRIMIDINE DERIVATIVES AS PDE4 INHIBITORS FOR THE TREATMENT OF INFLAMMATORY AND' IMMUNE DISEASES | AstraZeneca AB (SE) | 2008-05-21 | — | — | EP | disclosed |
| WO-2007004958-A1 | PYRIDOPYRIMIDINE DERIVATIVES AS PDE4 INHIBITORS FOR THE TREATMENT OF INFLAMMATORY AND' IMMUNE DISEASES | ASTRAZENECA AB (SE) | 2007-01-11 | — | — | WO | disclosed |