Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 7/20 | 0.49 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 5/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.42 |
| ▸ | GSK3A | P49840 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | GMNN | O75496 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TTR | P02766 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15638933 | 0.87 | DHODH (0.64) | DHODHCSNK2A1MEN1KMT2AGAA | |
| SCHEMBL15636037 | 0.84 | DHODH (0.58) | DHODHMEN1KMT2AGAAGFER | |
| SCHEMBL15635777 | 0.83 | LMNA (0.58) | DHODHCSNK2A1MEN1KMT2ALMNA | |
| SCHEMBL15636368 | 0.80 | DHODH (0.72) | DHODHMEN1KMT2AGAARAB9A | |
| SCHEMBL4879890 | 0.80 | PDE4B (0.49) | MEN1KMT2ARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL4879896 | 0.80 | PDE4B (0.49) | MEN1KMT2ARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL869587 | 0.80 | DHODH (0.46) | DHODHCSNK2A1MEN1KMT2ARAB9A | |
| SCHEMBL870223 | 0.80 | DHODH (0.53) | DHODHMEN1KMT2ALMNAPTGS2 | |
| SCHEMBL17110947 | 0.80 | SYK (0.51) | DHODHMEN1KMT2ARAB9ALMNA | |
| SCHEMBL870322 | 0.79 | DHODH (0.51) | DHODHMEN1KMT2AGAARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080227797-A1 | Pyridopyrimidine Derivatives as Pde4 Inhibitors for the Treatment of Inflammatory and Immune Diseases | ASTRAZENECA AB (SE) | 2008-09-18 | — | — | US | disclosed |
| EP-1922318-A1 | PYRIDOPYRIMIDINE DERIVATIVES AS PDE4 INHIBITORS FOR THE TREATMENT OF INFLAMMATORY AND' IMMUNE DISEASES | AstraZeneca AB (SE) | 2008-05-21 | — | — | EP | disclosed |
| WO-2007004958-A1 | PYRIDOPYRIMIDINE DERIVATIVES AS PDE4 INHIBITORS FOR THE TREATMENT OF INFLAMMATORY AND' IMMUNE DISEASES | ASTRAZENECA AB (SE) | 2007-01-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080227797-A1 | Pyridopyrimidine Derivatives as Pde4 Inhibitors for the Treatment of Inflammatory and Immune Diseases | PDE4A, PDE4B, PDE5A | DHODH 181/4885CSNK2A1 2018/4885MEN1 3231/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.