Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 7/20 | 0.53 |
| ▸ | SRC | P12931 | 7/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | JAK1 | P23458 | 1/20 | 0.46 |
| ▸ | CDK1 | P06493 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.43 |
| ▸ | YES1 | P07947 | 1/20 | 0.43 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6219889 | 0.85 | SRC (0.53) | SRCCDK1KDRSIGMAR1PDGFRB | |
| SCHEMBL4768085 | 0.84 | SRC (0.49) | SRCCDK1KDRPDGFRBYES1 | |
| SCHEMBL4766314 | 0.83 | SYK (0.71) | SYKJAK2JAK1CDK1 | |
| SCHEMBL4769132 | 0.82 | SYK (0.64) | SYKJAK2JAK1CDK1 | |
| SCHEMBL5723446 | 0.80 | SRC (0.49) | SRCCDK1KDRSIGMAR1PDGFRB | |
| SCHEMBL4765289 | 0.80 | CCNA2 (0.57) | SYK | |
| SCHEMBL4763434 | 0.79 | SYK (0.67) | SYKJAK2JAK1PDGFRB | |
| SCHEMBL4764044 | 0.78 | SYK (0.66) | SYKJAK2JAK1 | |
| SCHEMBL4775395 | 0.78 | SYK (0.60) | SYKJAK2JAK1PDGFRB | |
| SCHEMBL4772623 | 0.75 | SYK (0.54) | SYKJAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1303496-B9 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2008-03-19 | — | — | EP | disclosed |
| EP-1303496-B1 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2007-09-12 | — | — | EP | disclosed |