Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 16/20 | 0.49 |
| ▸ | PLK1 | P53350 | 1/20 | 0.46 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.46 |
| ▸ | PLK2 | Q9NYY3 | 1/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 5/20 | 0.44 |
| ▸ | YES1 | P07947 | 1/20 | 0.44 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.44 |
| ▸ | CDK1 | P06493 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | MERTK | Q12866 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4768575 | 0.85 | CHEK1 (0.46) | PLK1PLK3PLK2CDK1KDR | |
| SCHEMBL4770106 | 0.84 | SYK (0.53) | SRCPDGFRBYES1EPHB4CDK1 | |
| SCHEMBL4772259 | 0.83 | KMT2A (0.42) | PLK1PLK3PLK2CDK1KDR | |
| SCHEMBL4763831 | 0.83 | ALDH1A1 (0.52) | PLK1PLK3PLK2 | |
| SCHEMBL6219889 | 0.82 | SRC (0.53) | SRCPDGFRBYES1EPHB4CDK1 | |
| SCHEMBL4769260 | 0.82 | CA2 (0.48) | CDK1KDRCA2CA9 | |
| SCHEMBL4774308 | 0.81 | CCNA2 (0.54) | SRCABL1 | |
| SCHEMBL4763724 | 0.81 | CA2 (0.47) | CDK1KDRCA2CA9 | |
| SCHEMBL4770616 | 0.81 | RAB9A (0.48) | PLK1PLK3PLK2MERTKCA2 | |
| SCHEMBL4770543 | 0.80 | CA2 (0.42) | CDK1KDRABL1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1303496-B9 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2008-03-19 | — | — | EP | disclosed |
| EP-1303496-B1 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2007-09-12 | — | — | EP | disclosed |