Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 12/20 | 0.63 |
| ▸ | HSD11B2 | P80365 | 5/20 | 0.63 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.34 |
| ▸ | XDH | P47989 | 1/20 | 0.34 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.33 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL328769 | 0.78 | HSD11B1 (1.00) | HSD11B1HSD11B2 | |
| SCHEMBL328803 | 0.74 | HSD11B1 (0.63) | HSD11B1HSD11B2 | |
| SCHEMBL2720948 | 0.71 | HSD11B1 (0.85) | HSD11B1HSD11B2 | |
| SCHEMBL328946 | 0.71 | HSD11B1 (0.85) | HSD11B1HSD11B2 | |
| SCHEMBL328846 | 0.71 | HSD11B1 (0.85) | HSD11B1HSD11B2 | |
| SCHEMBL328843 | 0.67 | HSD11B1 (0.52) | HSD11B1HSD11B2 | |
| SCHEMBL2720258 | 0.67 | HSD11B1 (0.81) | HSD11B1HSD11B2 | |
| SCHEMBL2716665 | 0.67 | HSD11B1 (0.81) | HSD11B1HSD11B2 | |
| SCHEMBL4905160 | 0.66 | HSD11B1 (1.00) | HSD11B1HSD11B2 | |
| SCHEMBL328993 | 0.66 | HSD11B1 (1.00) | HSD11B1HSD11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2007719-A2 | INHIBITORS OF THE 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 ENZYME | Abbott Laboratories (US) | 2008-12-31 | — | — | EP | disclosed |
| WO-2007118185-A2 | INHIBITORS OF THE 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 ENZYME | ABBOTT LABORATORIES (US) | 2007-10-18 | — | — | WO | disclosed |