Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 17/20 | 0.56 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.41 |
| ▸ | RET | P07949 | 2/20 | 0.41 |
| ▸ | JAK1 | P23458 | 2/20 | 0.41 |
| ▸ | TYK2 | P29597 | 2/20 | 0.41 |
| ▸ | FLT3 | P36888 | 2/20 | 0.41 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.41 |
| ▸ | STK4 | Q13043 | 2/20 | 0.41 |
| ▸ | STK3 | Q13188 | 2/20 | 0.41 |
| ▸ | MARK2 | Q7KZI7 | 2/20 | 0.41 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.41 |
| ▸ | RPS6KA6 | Q9UK32 | 2/20 | 0.41 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | CSF1R | P07333 | 1/20 | 0.41 |
| ▸ | FLT4 | P35916 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4775395 | 0.90 | SYK (0.60) | SYKLRRK2AURKACHEK1RET | |
| SCHEMBL4763434 | 0.89 | SYK (0.67) | SYKLRRK2AURKACHEK1RET | |
| SCHEMBL4764044 | 0.82 | SYK (0.66) | SYKLRRK2AURKAJAK1TBK1 | |
| SCHEMBL4772623 | 0.82 | SYK (0.54) | SYKLRRK2AURKACHEK1JAK1 | |
| SCHEMBL4769208 | 0.81 | SYK (0.53) | SYKLRRK2AURKACHEK1 | |
| SCHEMBL4764141 | 0.79 | CDK2 (0.53) | SYKLRRK2AURKA | |
| SCHEMBL4766314 | 0.78 | SYK (0.71) | SYKJAK1JAK2 | |
| SCHEMBL4769132 | 0.75 | SYK (0.64) | SYKLRRK2JAK1JAK2 | |
| SCHEMBL4768983 | 0.75 | AURKA (0.53) | SYKLRRK2AURKARETFLT3 | |
| SCHEMBL4765289 | 0.73 | CCNA2 (0.57) | SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1303496-B9 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2008-03-19 | — | — | EP | disclosed |
| EP-1303496-B1 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2007-09-12 | — | — | EP | disclosed |