Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 16/20 | 0.53 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4772623 | 0.97 | SYK (0.54) | SYKCHEK1LRRK2AURKA | |
| SCHEMBL4775395 | 0.85 | SYK (0.60) | SYKCHEK1LRRK2AURKA | |
| SCHEMBL4763434 | 0.84 | SYK (0.67) | SYKCHEK1LRRK2AURKA | |
| SCHEMBL4770588 | 0.81 | SYK (0.56) | SYKCHEK1LRRK2AURKA | |
| SCHEMBL4764044 | 0.80 | SYK (0.66) | SYKLRRK2AURKA | |
| SCHEMBL5723394 | 0.80 | CDK2 (0.49) | SYKCHEK1 | |
| SCHEMBL4766314 | 0.78 | SYK (0.71) | SYK | |
| SCHEMBL4769132 | 0.77 | SYK (0.64) | SYKLRRK2 | |
| SCHEMBL4770106 | 0.74 | SYK (0.53) | SYK | |
| SCHEMBL4765289 | 0.73 | CCNA2 (0.57) | SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1303496-B9 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2008-03-19 | — | — | EP | disclosed |
| EP-1303496-B1 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2007-09-12 | — | — | EP | disclosed |