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Sugi Predict / Compounds / SCHEMBL4770640

SCHEMBL4770640

SCHEMBL4770640

CCN(CC)Cc1ccc(-c2cc3c(Nc4ccc(F)c(Cl)c4)ncnc3[nH]2)cc1

nearest known ligand 0.49

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ EGFR P00533 16/20 0.49
▸ KDR P35968 2/20 0.49
▸ FBP1 P09467 2/20 0.48
▸ ERBB2 P04626 5/20 0.47
▸ ERBB4 Q15303 4/20 0.47
▸ GRM1 Q13255 1/20 0.45
▸ AURKA O14965 1/20 0.45
▸ INSR P06213 1/20 0.45
▸ PDGFRB P09619 1/20 0.45
▸ FLT4 P35916 1/20 0.45
▸ CLK1 P49759 1/20 0.45
▸ EPHB4 P54760 1/20 0.45
▸ TEK Q02763 1/20 0.45
▸ AURKB Q96GD4 1/20 0.45
▸ RET P07949 1/20 0.44
▸ RAF1 P04049 1/20 0.43
▸ BRAF P15056 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4765640 0.90 EGFR (0.57) EGFRKDRFBP1ERBB2ERBB4
SCHEMBL4766773 0.90 EGFR (0.47) EGFRKDRFBP1ERBB2ERBB4
SCHEMBL4764231 0.88 EGFR (0.49) EGFRKDRFBP1ERBB2ERBB4
SCHEMBL4764395 0.86 EGFR (0.52) EGFRKDRFBP1ERBB2ERBB4
SCHEMBL4765608 0.86 EGFR (0.52) EGFRKDRFBP1ERBB2ERBB4
SCHEMBL4772678 0.85 EGFR (0.55) EGFRGRM1AURKA
SCHEMBL4766999 0.84 EGFR (0.62) EGFRKDRFBP1ERBB2ERBB4
SCHEMBL4766340 0.84 EGFR (0.48) EGFRKDRERBB2ERBB4AURKA
SCHEMBL7496670 0.84 EGFR (0.62) EGFRKDRFBP1ERBB2ERBB4
SCHEMBL4767298 0.83 EGFR (0.49) EGFRKDRFBP1ERBB2ERBB4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101560214-A 4-amino-6-phenyl-pyrrolo[2, 3-d]pyrimidine derivatives NOVARTIS AG (CH) 2009-10-21 — — CN claimed
EP-1416935-B1 4-AMINO-6-PHENYL-PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES NOVARTIS AG (CH) 2008-03-12 — — EP claimed
US-7244729-B2 4-amino-6-phenyl-pyrrolo[2,3-d]pyrimidine derivatives NOVARTIS AG (CH) 2007-07-17 — — US claimed
US-20040248911-A1 7H-pyrrolo[2,3-d]pyrimidine derivatives BOLD GUIDO (CH) 2004-12-09 — — US claimed
US-20040242600-A1 4-amino-6-phenyl-pyrrolo[2,3-d]pyrimidine derivatives NOVARTIS AG (CH) 2004-12-02 — — US claimed
CN-1538847-A 4-amino-6-phenyl-pyrrolo [2, 3-d ] pyrimidine derivatives ��˹��ŵ�� 2004-10-20 — — CN claimed
CN-101560214-B 4-amino-6-phenyl-pyrrolo[2, 3-d]pyrimidine derivatives NOVARTIS AG 2011-05-25 — — CN disclosed
CN-101560214-A 4-amino-6-phenyl-pyrrolo[2, 3-d]pyrimidine derivatives NOVARTIS AG (CH) 2009-10-21 — — CN disclosed
EP-1416935-B1 4-AMINO-6-PHENYL-PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES NOVARTIS AG (CH) 2008-03-12 — — EP disclosed
CN-1538847-A 4-amino-6-phenyl-pyrrolo [2, 3-d ] pyrimidine derivatives ��˹��ŵ�� 2004-10-20 — — CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040248911-A1 7H-pyrrolo[2,3-d]pyrimidine derivatives DPYD, DHPS, TYMP EGFR 3391/4885KDR 3031/4885FBP1 528/4885
US-20040242600-A1 4-amino-6-phenyl-pyrrolo[2,3-d]pyrimidine derivatives DPYD, TYMP, TYMS EGFR 2694/4885KDR 2234/4885FBP1 424/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.