SCHEMBL4770653

SCHEMBL4770653

CC(CCCCOC(=O)c1noc2ccccc12)=C(F)F

nearest known ligand 0.41

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
HIF1A Q16665 16/20 0.41
FAAH O00519 1/20 0.40
MGLL Q99685 1/20 0.40
FFAR4 Q5NUL3 1/20 0.39
HPGD P15428 1/20 0.37
MAPK1 P28482 1/20 0.37
HSD17B10 Q99714 1/20 0.37
TDP1 Q9NUW8 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4763784 0.79 KDM4E (0.61) HIF1AHPGDMAPK1HSD17B10
SCHEMBL4765659 0.78 TP53 (0.43) HPGDMAPK1HSD17B10TDP1
SCHEMBL30174438 0.76 KDM4E (0.52) HIF1AMAPK1
SCHEMBL1572943 0.76 KDM4E (0.52) HIF1AMAPK1
SCHEMBL4772607 0.74 HSD17B10 (0.62) HPGDMAPK1HSD17B10TDP1
SCHEMBL4769492 0.73 TSHR (0.41) MAPK1HSD17B10TDP1
SCHEMBL4766130 0.73 NPC1 (0.62) MAPK1TDP1
SCHEMBL4770615 0.73 APP (0.55) HSD17B10
SCHEMBL30615702 0.72 HIF1A (0.61) HIF1A
SCHEMBL4767304 0.71 NR4A2 (0.52) MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1439169-B1 DIFLUOROALKENE DERIVATIVE, PEST CONTROL AGENT CONTAINING THE SAME, AND INTERMEDIATE THEREFOR KUMIAI CHEMICAL INDUSTRY CO (JP) 2008-08-06 EP disclosed
US-7273878-B2 Difluoroalkene derivative, pest control agent containing the same, and intermediate therefor KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) 2007-09-25 US disclosed
US-20040248872-A1 Difluoroalkene derivative, pest control agent containing the same, and intermediate therefor IHARA CHEMICAL INDUSTRY CO., LTD. (JP) 2004-12-09 US disclosed
EP-1439169-A1 DIFLUOROALKENE DERIVATIVE, PEST CONTROL AGENT CONTAINING THE SAME, AND INTERMEDIATE THEREFOR KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) 2004-07-21 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040248872-A1 Difluoroalkene derivative, pest control agent containing the same, and intermediate therefor DDT, WEE1, NOTUM HIF1A 2218/4885FAAH 1262/4885MGLL 772/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.