Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.39 |
| ▸ | MEN1 | O00255 | 6/20 | 0.39 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 2/20 | 0.38 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.38 |
| ▸ | NAMPT | P43490 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3141747 | 0.79 | KDR (0.47) | KMT2AMEN1MAPTALDH1A1GAA | |
| SCHEMBL4773961 | 0.78 | PDPK1 (0.40) | KMT2AMEN1MAPTALDH1A1GAA | |
| SCHEMBL6223371 | 0.78 | KDR (0.48) | KMT2AMEN1MAPTALDH1A1GAA | |
| SCHEMBL447100 | 0.78 | ALDH1A1 (0.44) | KMT2AMEN1ALDH1A1NAMPTKDM4E | |
| SCHEMBL447011 | 0.76 | KDR (0.66) | KDRABCB1 | |
| SCHEMBL4773975 | 0.75 | MAPT (0.44) | KMT2AMEN1MAPTALDH1A1GAA | |
| SCHEMBL5626692 | 0.75 | PTGS1 (0.55) | KMT2AMEN1RAB9ANAMPTABCB1 | |
| SCHEMBL6105558 | 0.75 | KDR (0.56) | KMT2AMEN1MAPTALDH1A1GAA | |
| SCHEMBL4770421 | 0.75 | MEN1 (0.43) | KMT2AMEN1MAPTALDH1A1GAA | |
| SCHEMBL3156233 | 0.75 | KDR (0.51) | KMT2AMEN1MAPTKDRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1562933-B1 | SUBSTITUTED AMINE DERIVATIVES AND METHODS OF USE IN THE TREATMENT OF ANGIOGENESIS RELATED DISORDERS | AMGEN INC (US) | 2008-03-19 | — | — | EP | claimed |