Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1E | P49674 | 11/20 | 0.61 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.42 |
| ▸ | RIPK3 | Q9Y572 | 5/20 | 0.40 |
| ▸ | HTR3A | P46098 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL477081 | 1.00 | CSNK1E (0.61) | CSNK1EHRH4RIPK3HTR3A | |
| SCHEMBL477083 | 1.00 | CSNK1E (0.61) | CSNK1EHRH4RIPK3HTR3A | |
| SCHEMBL3114648 | 0.85 | CSNK1E (0.65) | CSNK1EHRH4RIPK3 | |
| SCHEMBL3121838 | 0.85 | CSNK1E (0.65) | CSNK1EHRH4RIPK3 | |
| SCHEMBL3108559 | 0.85 | CSNK1E (0.65) | CSNK1EHRH4RIPK3 | |
| SCHEMBL3116720 | 0.84 | CSNK1E (0.66) | CSNK1EHRH4RIPK3 | |
| SCHEMBL3112002 | 0.84 | CSNK1E (0.66) | CSNK1EHRH4RIPK3 | |
| SCHEMBL477021 | 0.83 | CSNK1E (0.49) | CSNK1EHRH4RIPK3 | |
| SCHEMBL477020 | 0.83 | CSNK1E (0.49) | CSNK1EHRH4RIPK3 | |
| SCHEMBL477018 | 0.83 | CSNK1E (0.49) | CSNK1EHRH4RIPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110312934-A1 | 2-ALKYL-6-CYCLOAMINO-3-(PYRIDIN-4-YL)IMIDAZO[1,2-B]-PYRIDAZINE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC APPLICATION THEREOF | SANOFI-AVENTIS (FR) | 2011-12-22 | — | — | US | claimed |
| EP-2331546-B1 | 2-ALKYL-6-CYCLOAMINO-3-(PYRIDIN-4-YL)IMIDAZO[1,2-IB]-PYRIDAZINE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC APPLICATION THEREOF | SANOFI SA (FR) | 2012-02-01 | — | — | EP | disclosed |
| US-20110312934-A1 | 2-ALKYL-6-CYCLOAMINO-3-(PYRIDIN-4-YL)IMIDAZO[1,2-B]-PYRIDAZINE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC APPLICATION THEREOF | SANOFI-AVENTIS (FR) | 2011-12-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110312934-A1 | 2-ALKYL-6-CYCLOAMINO-3-(PYRIDIN-4-YL)IMIDAZO[1,2-B]-PYRIDAZINE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC APPLICATION THEREOF | NR3C1, CNKSR1, NR3C2 | CSNK1E 2760/4885HRH4 10/4885RIPK3 4284/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.