Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | GHSR | Q92847 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27434483 | 0.76 | RXFP1 (0.56) | PDE10ARXFP1KMT2ALMNATHRB | |
| SCHEMBL30954136 | 0.76 | RXFP1 (0.56) | PDE10ARXFP1KMT2ALMNATHRB | |
| SCHEMBL27432476 | 0.75 | RXFP1 (0.46) | PDE10ARXFP1KMT2ALMNATHRB | |
| SCHEMBL27433242 | 0.75 | POLB (0.47) | PDE10ARXFP1KMT2ALMNATHRB | |
| SCHEMBL30954097 | 0.75 | POLB (0.47) | PDE10ARXFP1KMT2ALMNATHRB | |
| SCHEMBL1494271 | 0.73 | RXFP1 (0.46) | PDE10ARXFP1KMT2ALMNATHRB | |
| SCHEMBL1494287 | 0.72 | RXFP1 (0.45) | PDE10ARXFP1KMT2ALMNATHRB | |
| SCHEMBL31017016 | 0.72 | RXFP1 (0.46) | PDE10ARXFP1KMT2ALMNATHRB | |
| SCHEMBL3957011 | 0.71 | PPARG (0.50) | KMT2ALMNATHRB | |
| SCHEMBL21798818 | 0.71 | TAAR1 (0.45) | KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1924264-A1 | DIAMINOPYRIMIDINES AS P2X3 AND P2X2/3 MODULATORS | F.HOFFMANN-LA ROCHE AG (CH) | 2008-05-28 | — | — | EP | disclosed |
| WO-2007025925-A1 | DIAMINOPYRIMIDINES AS P2X3 AND P2X2/3 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-03-08 | — | — | WO | disclosed |