Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 20/20 | 0.51 |
| ▸ | ADORA1 | P30542 | 13/20 | 0.51 |
| ▸ | ADORA2A | P29274 | 12/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 7/20 | 0.47 |
| ▸ | PLK4 | O00444 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.43 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.43 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.43 |
| ▸ | CSNK1G3 | Q9Y6M4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4763167 | 0.92 | ADORA2B (0.55) | ADORA2BADORA1ADORA2AADORA3PLK4 | |
| SCHEMBL4766120 | 0.91 | ADORA2B (0.54) | ADORA2BADORA1ADORA2AADORA3 | |
| SCHEMBL4769108 | 0.89 | ADORA2B (0.59) | ADORA2BADORA1ADORA2AADORA3 | |
| SCHEMBL4769007 | 0.88 | ADORA2B (0.57) | ADORA2BADORA1ADORA2AADORA3 | |
| SCHEMBL4771393 | 0.87 | ADORA2B (0.53) | ADORA2BADORA1ADORA2AADORA3 | |
| SCHEMBL4767588 | 0.87 | ADORA2B (0.52) | ADORA2BADORA1ADORA2AADORA3 | |
| SCHEMBL4769231 | 0.86 | ADORA2B (0.51) | ADORA2BADORA1ADORA2AADORA3 | |
| SCHEMBL4769556 | 0.85 | ADORA2B (0.55) | ADORA2BADORA1ADORA2AADORA3 | |
| SCHEMBL4767464 | 0.85 | ADORA2B (0.51) | ADORA2BADORA1ADORA2AADORA3 | |
| SCHEMBL4769313 | 0.84 | ADORA2B (0.47) | ADORA2BADORA1ADORA2AADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678181-B1 | A2B ADENOSINE RECEPTOR ANTAGONISTS | CV THERAPEUTICS INC (US) | 2008-12-31 | — | — | EP | disclosed |