Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKN1 | Q16512 | 3/20 | 1.00 |
| ▸ | PKN2 | Q16513 | 3/20 | 1.00 |
| ▸ | CDC7 | O00311 | 13/20 | 0.65 |
| ▸ | MAPKAPK2 | P49137 | 3/20 | 0.56 |
| ▸ | CDK9 | P50750 | 2/20 | 0.56 |
| ▸ | CDK1 | P06493 | 2/20 | 0.56 |
| ▸ | MAPKAPK3 | Q16644 | 2/20 | 0.56 |
| ▸ | MAPKAPK5 | Q8IW41 | 2/20 | 0.56 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.56 |
| ▸ | PLK4 | O00444 | 1/20 | 0.56 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.56 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.56 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.56 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.56 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.56 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.56 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.56 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.56 |
| ▸ | PRKACA | P17612 | 1/20 | 0.56 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4791535 | 1.00 | PKN1 (1.00) | PKN1PKN2CDC7MAPKAPK2CDK9 | |
| SCHEMBL4773024 | 0.80 | CDC7 (0.75) | PKN1PKN2CDC7MAPKAPK2CDK9 | |
| SCHEMBL4765968 | 0.80 | CDC7 (0.75) | PKN1PKN2CDC7MAPKAPK2CDK9 | |
| SCHEMBL4773017 | 0.80 | CDC7 (0.75) | PKN1PKN2CDC7MAPKAPK2CDK9 | |
| SCHEMBL4771895 | 0.79 | CDC7 (1.00) | PKN1PKN2CDC7MAPKAPK2CDK9 | |
| SCHEMBL4794071 | 0.79 | CDC7 (1.00) | PKN1PKN2CDC7MAPKAPK2CDK9 | |
| Hydrochloric Acid SCHEMBL4773043 | 0.78 | CDC7 (0.97) | PKN1PKN2CDC7MAPKAPK2CDK9 | |
| SCHEMBL4768712 | 0.78 | CDC7 (0.72) | PKN1PKN2CDC7MAPKAPK2CDK9 | |
| SCHEMBL4768715 | 0.78 | CDC7 (0.72) | PKN1PKN2CDC7MAPKAPK2CDK9 | |
| SCHEMBL4766378 | 0.77 | CDC7 (1.00) | PKN1PKN2CDC7MAPKAPK2CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1660085-B1 | PYRIDYLPYRROLE DERIVATIVES ACTIVE AS KINASE INHIBITORS | PFIZER ITALIA SRL (IT) | 2008-10-15 | — | — | EP | claimed |
| US-20050043346-A1 | Pyridylpyrrole derivatives active as kinase inhibitors | PHARMACIA ITALIA S.P.A. (IT) | 2005-02-24 | — | — | US | claimed |
| EP-1660085-B1 | PYRIDYLPYRROLE DERIVATIVES ACTIVE AS KINASE INHIBITORS | PFIZER ITALIA SRL (IT) | 2008-10-15 | — | — | EP | disclosed |
| EP-1660085-A1 | PYRIDYLPYRROLE DERIVATIVES ACTIVE AS KINASE INHIBITORS | Pharmacia Italia S.p.A. (IT) | 2006-05-31 | — | — | EP | disclosed |
| US-20050043346-A1 | Pyridylpyrrole derivatives active as kinase inhibitors | PHARMACIA ITALIA S.P.A. (IT) | 2005-02-24 | — | — | US | disclosed |
| WO-2005013986-A1 | PYRIDYLPYRROLE DERIVATIVES ACTIVE AS KINASE INHIBITORS | PHARMACIA ITALIA S.P.A. (IT) | 2005-02-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050043346-A1 | Pyridylpyrrole derivatives active as kinase inhibitors | MAP3K6, MAP3K5, MAP4K2 | PKN1 91/4885PKN2 82/4885CDC7 426/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.