Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 17/20 | 0.70 |
| ▸ | TNNI3K | Q59H18 | 15/20 | 0.70 |
| ▸ | MAPK14 | Q16539 | 14/20 | 0.70 |
| ▸ | BRAF | P15056 | 13/20 | 0.70 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.63 |
| ▸ | RAF1 | P04049 | 2/20 | 0.63 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.63 |
| ▸ | STK25 | O00506 | 1/20 | 0.63 |
| ▸ | CIT | O14578 | 1/20 | 0.63 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.63 |
| ▸ | IKBKB | O14920 | 1/20 | 0.63 |
| ▸ | AURKA | O14965 | 1/20 | 0.63 |
| ▸ | GAK | O14976 | 1/20 | 0.63 |
| ▸ | CHUK | O15111 | 1/20 | 0.63 |
| ▸ | MUSK | O15146 | 1/20 | 0.63 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.63 |
| ▸ | MAP3K13 | O43283 | 1/20 | 0.63 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.63 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.63 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4937968 | 0.97 | KDR (0.69) | KDRTNNI3KMAPK14BRAFMKNK2 | |
| SCHEMBL4769465 | 0.93 | KDR (0.65) | KDRTNNI3KMAPK14BRAFMKNK2 | |
| SCHEMBL4937778 | 0.91 | KDR (0.61) | KDRTNNI3KMAPK14BRAFMKNK2 | |
| SCHEMBL4762311 | 0.88 | KDR (0.67) | KDRTNNI3KMAPK14BRAFMKNK2 | |
| SCHEMBL4932639 | 0.86 | KDR (0.64) | KDRTNNI3KMAPK14BRAFMKNK2 | |
| SCHEMBL4932660 | 0.86 | KDR (0.66) | KDRTNNI3KMAPK14BRAFMKNK2 | |
| SCHEMBL4929725 | 0.85 | KDR (0.72) | KDRTNNI3KMAPK14BRAFRAF1 | |
| SCHEMBL4929381 | 0.85 | KDR (0.72) | KDRTNNI3KMAPK14BRAFRAF1 | |
| SCHEMBL4763945 | 0.84 | KDR (0.86) | KDRTNNI3KMAPK14BRAFMKNK2 | |
| SCHEMBL13991466 | 0.84 | KDR (0.61) | KDRTNNI3KMAPK14BRAFMKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1511730-B1 | DIARYL UREA DERIVATIVES USEFUL FOR THE TREATMENT OF PROTEIN KINASE DEPENDENT DISEASES | NOVARTIS AG (CH) | 2008-12-10 | — | — | EP | claimed |