Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 19/20 | 0.72 |
| ▸ | TNNI3K | Q59H18 | 18/20 | 0.72 |
| ▸ | MAPK14 | Q16539 | 16/20 | 0.72 |
| ▸ | BRAF | P15056 | 14/20 | 0.72 |
| ▸ | RAF1 | P04049 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4929725 | 0.91 | KDR (0.72) | KDRTNNI3KMAPK14BRAFRAF1 | |
| SCHEMBL4936555 | 0.88 | KDR (0.67) | KDRTNNI3KMAPK14BRAFRAF1 | |
| SCHEMBL4937968 | 0.86 | KDR (0.69) | KDRTNNI3KMAPK14BRAFRAF1 | |
| SCHEMBL4771607 | 0.85 | KDR (0.70) | KDRTNNI3KMAPK14BRAFRAF1 | |
| SCHEMBL4769465 | 0.85 | KDR (0.65) | KDRTNNI3KMAPK14BRAFRAF1 | |
| SCHEMBL4932582 | 0.84 | KDR (0.73) | KDRTNNI3KMAPK14BRAFRAF1 | |
| SCHEMBL4933023 | 0.84 | KDR (0.73) | KDRTNNI3KMAPK14BRAFRAF1 | |
| SCHEMBL3171768 | 0.84 | KDR (1.00) | KDRTNNI3KMAPK14BRAFRAF1 | |
| SCHEMBL4937778 | 0.83 | KDR (0.61) | KDRTNNI3KMAPK14BRAFRAF1 | |
| SCHEMBL13991478 | 0.80 | KDR (0.59) | KDRTNNI3KMAPK14BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080312192-A1 | Diaryl Urea Derivatives in the Treatment of Protein Kinase Dependent Diseases | BOLD GUIDO | 2008-12-18 | — | — | US | claimed |
| US-20080312192-A1 | Diaryl Urea Derivatives in the Treatment of Protein Kinase Dependent Diseases | BOLD GUIDO | 2008-12-18 | — | — | US | disclosed |
| US-20080312192-A1 | Diaryl Urea Derivatives in the Treatment of Protein Kinase Dependent Diseases | BOLD GUIDO | 2008-12-18 | — | — | US | disclosed |
| US-20080312192-A1 | Diaryl Urea Derivatives in the Treatment of Protein Kinase Dependent Diseases | BOLD GUIDO | 2008-12-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080312192-A1 | Diaryl Urea Derivatives in the Treatment of Protein Kinase Dependent Diseases | RET, PRKDC, PRKACA | KDR 1309/4885TNNI3K 314/4885MAPK14 343/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.