Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | STAT1 | P42224 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24517751 | 0.83 | KMT2A (0.41) | KMT2AMAPTSMN1; SMN2MEN1LMNA | |
| SCHEMBL3275633 | 0.81 | CYP1A2 (0.53) | KMT2AMAPTSMN1; SMN2MEN1LMNA | |
| SCHEMBL15772429 | 0.81 | MCHR1 (0.46) | KMT2AMAPTSMN1; SMN2MEN1LMNA | |
| SCHEMBL7420941 | 0.80 | CYP1A2 (0.55) | KMT2AMAPTSMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL26725170 | 0.79 | PLAU (0.49) | KMT2AALDH1A1IRAK4 | |
| SCHEMBL15772680 | 0.78 | NQO1 (0.47) | ALDH1A1KDM4EHPGDHSD17B10IRAK4 | |
| SCHEMBL27729420 | 0.77 | KMT2A (0.39) | KMT2AMAPTSMN1; SMN2MEN1LMNA | |
| SCHEMBL3275120 | 0.77 | MTNR1A (0.44) | KMT2AMAPTSMN1; SMN2MEN1LMNA | |
| SCHEMBL276584 | 0.75 | CYP1A2 (0.58) | KMT2AMAPTSMN1; SMN2MEN1TP53 | |
| SCHEMBL29233676 | 0.75 | CYP1A2 (0.48) | KMT2AMAPTMEN1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966134-A1 | NOVEL FUSED PYRROLE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2008-09-10 | — | — | EP | disclosed |
| WO-2007068621-A1 | NOVEL FUSED PYRROLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-06-21 | — | — | WO | disclosed |