Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 2/20 | 0.46 |
| ▸ | CDC7 | O00311 | 4/20 | 0.40 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | CDK5 | Q00535 | 5/20 | 0.37 |
| ▸ | CDK5R1 | Q15078 | 5/20 | 0.37 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
| ▸ | MMP13 | P45452 | 1/20 | 0.37 |
| ▸ | MMP14 | P50281 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | BUB1 | O43683 | 1/20 | 0.35 |
| ▸ | ACACB | O00763 | 1/20 | 0.35 |
| ▸ | ACACA | Q13085 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4830885 | 0.96 | GCGR (0.44) | GCGRCDC7AAK1MAPK14CDK5 | |
| SCHEMBL4767710 | 0.86 | GCGR (0.49) | GCGRCDC7AAK1MAPK14CDK5 | |
| SCHEMBL6466255 | 0.85 | KDM4E (0.35) | MMP13CASP1ACACBACACA | |
| SCHEMBL4774859 | 0.85 | GCGR (0.48) | GCGRCDC7AAK1MAPK14CDK5 | |
| SCHEMBL4767661 | 0.82 | GCGR (0.46) | GCGRCDC7AAK1MAPK14CDK5 | |
| SCHEMBL4771352 | 0.82 | ATM (0.46) | GCGRCDC7AAK1CDK5CDK5R1 | |
| Hydrochloric Acid SCHEMBL4775133 | 0.80 | GCGR (0.52) | GCGRCDC7MAPK14CDK5CDK5R1 | |
| SCHEMBL4768810 | 0.79 | GCGR (0.51) | GCGRCDC7AAK1MAPK14CDK5 | |
| Hydrochloric Acid SCHEMBL4765927 | 0.75 | GCGR (0.49) | GCGRCDC7MAPK14CDK5CDK5R1 | |
| SCHEMBL5346356 | 0.75 | GCGR (0.53) | GCGRCDC7AAK1MAPK14CDK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1660085-B1 | PYRIDYLPYRROLE DERIVATIVES ACTIVE AS KINASE INHIBITORS | PFIZER ITALIA SRL (IT) | 2008-10-15 | — | — | EP | disclosed |