Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 3/20 | 0.53 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.42 |
| ▸ | CDK5R1 | Q15078 | 3/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | CDC7 | O00311 | 5/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
| ▸ | MMP14 | P50281 | 1/20 | 0.40 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.39 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.39 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4768810 | 0.80 | GCGR (0.51) | GCGRMAPK14CDK5CDK5R1CASP1 | |
| SCHEMBL4775802 | 0.78 | GCGR (0.49) | GCGRMAPK14CDK5CDK5R1CASP1 | |
| SCHEMBL4767710 | 0.78 | GCGR (0.49) | GCGRMAPK14CDK5CDK5R1CASP1 | |
| SCHEMBL4774859 | 0.77 | GCGR (0.48) | GCGRMAPK14CDK5CDK5R1CASP1 | |
| SCHEMBL4174038 | 0.75 | GCGR (0.66) | GCGRMAPK14CDK5CDK5R1CASP1 | |
| SCHEMBL4182065 | 0.75 | GCGR (0.86) | GCGRMAPK14CASP1CDC7MMP2 | |
| SCHEMBL4771823 | 0.75 | GCGR (0.46) | GCGRMAPK14CDK5CDK5R1CASP1 | |
| SCHEMBL4767661 | 0.75 | GCGR (0.46) | GCGRMAPK14CDK5CDK5R1CDC7 | |
| SCHEMBL15230740 | 0.74 | PIM1 (0.54) | PIM1 | |
| SCHEMBL4771352 | 0.74 | ATM (0.46) | GCGRCDK5CDK5R1CDC7AAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007096334-A1 | PYRROLOPYRROLONES ACTIVE AS KINASE INHIBITORS | PFIZER ITALIA SRL (IT) | 2007-08-30 | — | — | WO | disclosed |