Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 2/20 | 0.44 |
| ▸ | DRD3 | P35462 | 2/20 | 0.44 |
| ▸ | DRD1 | P21728 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 1/20 | 0.44 |
| ▸ | DRD5 | P21918 | 1/20 | 0.44 |
| ▸ | RORC | P51449 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.42 |
| ▸ | KDM2B | Q8NHM5 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4024282 | 0.87 | SLC18A3 (0.45) | KMT2AMEN1KCNH2RORCALDH1A1 | |
| SCHEMBL4026119 | 0.87 | SLC18A3 (0.45) | KMT2AMEN1KCNH2RORCALDH1A1 | |
| SCHEMBL4019381 | 0.86 | KMT2A (0.46) | KMT2AMEN1RORCALDH1A1LMNA | |
| SCHEMBL4019373 | 0.86 | KMT2A (0.46) | KMT2AMEN1RORCALDH1A1LMNA | |
| SCHEMBL4026548 | 0.86 | KMT2A (0.46) | KMT2AMEN1RORCALDH1A1LMNA | |
| SCHEMBL4028249 | 0.85 | HRH3 (0.45) | KMT2AMEN1HRH3KCNH2RORC | |
| SCHEMBL4774189 | 0.85 | NTRK1 (0.43) | KMT2AMEN1DRD3RORCALDH1A1 | |
| SCHEMBL4027487 | 0.85 | HRH3 (0.45) | KMT2AMEN1HRH3KCNH2RORC | |
| SCHEMBL4019229 | 0.85 | NTRK1 (0.43) | KMT2AMEN1DRD3RORCALDH1A1 | |
| SCHEMBL4772338 | 0.85 | HRH3 (0.45) | KMT2AMEN1HRH3KCNH2RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1962846-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2008-09-03 | — | — | EP | claimed |
| WO-2007059323-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2007-05-24 | — | — | WO | claimed |
| EP-1962846-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2008-09-03 | — | — | EP | disclosed |
| WO-2007059323-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2007-05-24 | — | — | WO | disclosed |