Sugi Predict

Sugi Predict / Compounds / SCHEMBL4028249

SCHEMBL4028249

SCHEMBL4028249

CN(C)CCN1C[C@H](C(=O)c2ccccc2)C(c2ccccc2)[C@@H](C(=O)c2ccccc2)C1

nearest known ligand 0.50

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ HRH3 Q9Y5N1 2/20 0.45
▸ KMT2A Q03164 3/20 0.42
▸ MEN1 O00255 1/20 0.42
▸ RORC P51449 1/20 0.42
▸ ALDH1A1 P00352 4/20 0.38
▸ LMNA P02545 2/20 0.38
▸ GAA P10253 2/20 0.38
▸ KCNH2 Q12809 1/20 0.37
▸ OPRM1 P35372 1/20 0.37
▸ KDM4E B2RXH2 2/20 0.37
▸ MAPT P10636 1/20 0.37
▸ PTK2B Q14289 1/20 0.37
▸ ESR2 Q92731 1/20 0.37
▸ KDM1A O60341 1/20 0.37
▸ HTR2A P28223 1/20 0.36
▸ SIGMAR1 Q99720 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13721498 1.00 HRH3 (0.45) HRH3KMT2AMEN1RORCALDH1A1
SCHEMBL4772338 1.00 HRH3 (0.45) HRH3KMT2AMEN1RORCALDH1A1
SCHEMBL4027493 1.00 HRH3 (0.45) HRH3KMT2AMEN1RORCALDH1A1
SCHEMBL4027487 1.00 HRH3 (0.45) HRH3KMT2AMEN1RORCALDH1A1
SCHEMBL4018682 0.88 RORC (0.45) HRH3KMT2AMEN1RORCALDH1A1
SCHEMBL4021407 0.88 RORC (0.45) HRH3KMT2AMEN1RORCALDH1A1
SCHEMBL4772340 0.85 KMT2A (0.48) HRH3KMT2AMEN1RORCALDH1A1
SCHEMBL4021517 0.84 HRH3 (0.42) HRH3KMT2AMEN1RORCALDH1A1
SCHEMBL4780139 0.84 HRH3 (0.42) HRH3KMT2AMEN1RORCALDH1A1
SCHEMBL4024282 0.83 SLC18A3 (0.45) KMT2AMEN1RORCALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7572814-B2 3,5-dibenzoyl-4-phenyl-piperidine anti-cancer compounds CYTOKINETICS, INCORPORATED (US) 2009-08-11 — — US disclosed
US-7572814-B2 3,5-dibenzoyl-4-phenyl-piperidine anti-cancer compounds CYTOKINETICS, INCORPORATED (US) 2009-08-11 — — US disclosed
US-7572814-B2 3,5-dibenzoyl-4-phenyl-piperidine anti-cancer compounds CYTOKINETICS, INCORPORATED (US) 2009-08-11 — — US disclosed
WO-2008140810-A1 CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS CYTOKINETICS, INCORPORATED (US) 2008-11-20 — — WO disclosed
EP-1962846-A2 CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS Cytokinetics, Inc. (US) 2008-09-03 — — EP disclosed
US-20070161674-A1 Certain chemical entities, compositions, and methods CYTOKINETICS, INC. 2007-07-12 — — US disclosed
US-20070161674-A1 Certain chemical entities, compositions, and methods CYTOKINETICS, INC. 2007-07-12 — — US disclosed
US-20070161674-A1 Certain chemical entities, compositions, and methods CYTOKINETICS, INC. 2007-07-12 — — US disclosed
WO-2007059323-A2 CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS CYTOKINETICS, INC. (US) 2007-05-24 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070161674-A1 Certain chemical entities, compositions, and methods TP53, VHL, RB1 HRH3 1935/4885KMT2A 2820/4885MEN1 77/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.