Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1E | P49674 | 7/20 | 0.49 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.34 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.33 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | JAK1 | P23458 | 1/20 | 0.31 |
| ▸ | JAK3 | P52333 | 1/20 | 0.31 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.31 |
| ▸ | PIM1 | P11309 | 1/20 | 0.31 |
| ▸ | LATS1 | O95835 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL477008 | 0.86 | CSNK1E (0.63) | CSNK1EEIF2AK4PRKD1PRKD2PRKCQ | |
| SCHEMBL477012 | 0.80 | CSNK1E (0.58) | CSNK1EEIF2AK4PRKD1PRKD2PRKCQ | |
| SCHEMBL477013 | 0.78 | CSNK1E (0.59) | CSNK1EEIF2AK4PRKD1PRKD2PRKCQ | |
| SCHEMBL1746568 | 0.77 | CSNK1E (0.77) | CSNK1ELATS1 | |
| SCHEMBL477079 | 0.76 | CSNK1E (0.57) | CSNK1EEIF2AK4PRKD1PRKD2PRKCQ | |
| SCHEMBL3114281 | 0.76 | CSNK1E (0.81) | CSNK1EEIF2AK4PRKD1PRKD2PIM1 | |
| SCHEMBL3123887 | 0.75 | CSNK1E (0.80) | CSNK1EEIF2AK4PRKD1PRKD2PIM1 | |
| SCHEMBL3115509 | 0.75 | CSNK1E (0.68) | CSNK1EEIF2AK4PRKD1PRKD2PIM1 | |
| SCHEMBL3107009 | 0.70 | CSNK1E (0.79) | CSNK1EEIF2AK4PRKD1PRKD2PRKCQ | |
| SCHEMBL477077 | 0.69 | CSNK1E (0.57) | CSNK1E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2331546-B1 | 2-ALKYL-6-CYCLOAMINO-3-(PYRIDIN-4-YL)IMIDAZO[1,2-IB]-PYRIDAZINE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC APPLICATION THEREOF | SANOFI SA (FR) | 2012-02-01 | — | — | EP | claimed |