Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 1/20 | 0.64 |
| ▸ | S1PR5 | Q9H228 | 3/20 | 0.49 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | EP300 | Q09472 | 1/20 | 0.48 |
| ▸ | FUCA1 | P04066 | 2/20 | 0.47 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | HTR2B | P41595 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4022773 | 1.00 | RORC (0.64) | RORCS1PR5S1PR1ALDH1A1MEN1 | |
| SCHEMBL4792902 | 0.93 | RORC (0.58) | RORCS1PR5S1PR1ALDH1A1MEN1 | |
| SCHEMBL6998474 | 0.89 | RORC (0.68) | RORCS1PR5S1PR1ALDH1A1MEN1 | |
| SCHEMBL16033505 | 0.87 | RORC (0.83) | RORCS1PR5S1PR1ALDH1A1MEN1 | |
| SCHEMBL4772392 | 0.86 | RORC (0.51) | RORCALDH1A1MEN1KMT2A | |
| SCHEMBL5478531 | 0.82 | RORC (0.61) | RORCS1PR5S1PR1ALDH1A1MEN1 | |
| SCHEMBL4024282 | 0.82 | SLC18A3 (0.45) | RORCALDH1A1MEN1LMNAMAPK1 | |
| SCHEMBL5478523 | 0.82 | RORC (0.61) | RORCS1PR5S1PR1ALDH1A1MEN1 | |
| SCHEMBL5478527 | 0.82 | RORC (0.61) | RORCS1PR5S1PR1ALDH1A1MEN1 | |
| SCHEMBL4026119 | 0.82 | SLC18A3 (0.45) | RORCALDH1A1MEN1LMNAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1962846-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2008-09-03 | — | — | EP | claimed |
| WO-2007059323-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2007-05-24 | — | — | WO | claimed |
| EP-1962846-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2008-09-03 | — | — | EP | disclosed |
| WO-2007059323-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2007-05-24 | — | — | WO | disclosed |