Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.32 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.32 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.32 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.32 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3966494 | 0.78 | HTR2A (0.43) | ALDH1A1POLBMAPTCYP2C9CYP2C19 | |
| SCHEMBL14115776 | 0.69 | HTR2C (0.46) | ALDH1A1POLBKMT2AMAPTCYP2C9 | |
| SCHEMBL7261352 | 0.67 | ALDH1A1 (0.47) | SMN1; SMN2ALDH1A1POLBKMT2AMEN1 | |
| SCHEMBL11173610 | 0.66 | ALDH1A1 (0.46) | SMN1; SMN2ALDH1A1POLBKMT2AMEN1 | |
| SCHEMBL2118226 | 0.66 | ALDH1A1 (0.46) | SMN1; SMN2ALDH1A1POLBKMT2AMEN1 | |
| SCHEMBL31169794 | 0.65 | NOTUM (0.75) | ALDH1A1KMT2AMEN1NOTUMMAPT | |
| SCHEMBL11743398 | 0.65 | SMN1; SMN2 (0.60) | SMN1; SMN2ALDH1A1POLBKMT2AMEN1 | |
| SCHEMBL22662832 | 0.65 | SMN1; SMN2 (0.50) | SMN1; SMN2ALDH1A1POLBKMT2AMEN1 | |
| SCHEMBL13843636 | 0.64 | ALDH1A1 (0.47) | SMN1; SMN2ALDH1A1POLBKMT2AMEN1 | |
| SCHEMBL13946707 | 0.64 | SMN1; SMN2 (0.59) | SMN1; SMN2ALDH1A1POLBKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1926712-A1 | 6-SUBSTITUTED 2,3,4,5-TETRAHYDRO-1H-BENZO[D]AZEPINES AS 5-HT2C RECEPTOR AGONISTS | ELI LILLY AND COMPANY (US) | 2008-06-04 | — | — | EP | disclosed |
| WO-2007028131-A1 | 6-SUBSTITUTED 2,3,4,5-TETRAHYDRO-1H-BENZO[d]AZEPINES AS 5-HT2C RECEPTOR AGONISTS | ELI LILLY AND COMPANY (US) | 2007-03-08 | — | — | WO | disclosed |