Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | P2RY12 | Q9H244 | 7/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21815329 | 0.85 | NR1H2 (0.54) | KMT2AMEN1MAPTSMN1; SMN2TSHR | |
| SCHEMBL21815333 | 0.83 | ABL1 (0.44) | KMT2AMEN1MAPTSMN1; SMN2RXFP1 | |
| SCHEMBL4770618 | 0.78 | ABL1 (0.51) | KMT2AMAPTSMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL4765249 | 0.77 | SMN1; SMN2 (0.61) | KMT2AMEN1SMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL16334850 | 0.77 | P2RY12 (0.54) | KMT2AMEN1MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL29943640 | 0.75 | CSNK1A1 (0.50) | KMT2AMEN1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL26101400 | 0.75 | CSNK1A1 (0.50) | KMT2AMEN1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL24477792 | 0.74 | CSNK1A1 (0.49) | KMT2AMEN1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL29631702 | 0.74 | CSNK1A1 (0.49) | KMT2AMEN1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL4770277 | 0.74 | KDM4E (0.43) | RAB9AMAPTSMN1; SMN2HPGDLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1303496-B9 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2008-03-19 | — | — | EP | disclosed |
| EP-1303496-B1 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2007-09-12 | — | — | EP | disclosed |
| US-6908920-B2 | Pyrimidine derivatives | ASTRAZENECA AB (SE) | 2005-06-21 | — | — | US | disclosed |
| CN-1196685-C | Pyrimidine derivatives | ASTRAZENCA AB (SE) | 2005-04-13 | — | — | CN | disclosed |
| CN-1454210-A | Pyrimidine derivatives | ASTRAZENCA AB (SE) | 2003-11-05 | — | — | CN | disclosed |