Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.32 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2127522 | 0.85 | MAPT (0.44) | MAPTGAAALDH1A1NPC1KMT2A | |
| SCHEMBL22615393 | 0.83 | ADORA1 (0.44) | MAPTALDH1A1KMT2AHPGDKDM4E | |
| SCHEMBL4760227 | 0.83 | ADORA1 (0.44) | MAPTALDH1A1KMT2AHPGDKDM4E | |
| SCHEMBL16516481 | 0.79 | MAPT (0.42) | MAPTL3MBTL1GAAALDH1A1CYP2D6 | |
| SCHEMBL23039821 | 0.77 | MAPT (0.43) | MAPTGAAALDH1A1NPC1KMT2A | |
| SCHEMBL2847021 | 0.76 | MAPT (0.39) | MAPTALDH1A1KMT2AMEN1 | |
| SCHEMBL17505316 | 0.76 | ALDH1A1 (0.40) | MAPTALDH1A1KMT2AHPGDKDM4E | |
| SCHEMBL4948411 | 0.76 | MEN1 (0.54) | MAPTL3MBTL1GAAALDH1A1LMNA | |
| SCHEMBL542220 | 0.75 | MEN1 (0.47) | MAPTGAAALDH1A1NPC1KMT2A | |
| SCHEMBL5109918 | 0.75 | CYP2D6 (0.42) | MAPTL3MBTL1GAAALDH1A1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113767102-A | Novel phenyl and pyridylureas having activity against Hepatitis B Virus (HBV) | 艾库里斯有限及两合公司 | 2021-12-07 | — | — | CN | disclosed |
| EP-3036230-A1 | ALKYNYL ALCOHOLS AND METHODS OF USE | F. Hoffmann-La Roche AG (CH) | 2016-06-29 | — | — | EP | disclosed |
| WO-2015025025-A1 | ALKYNYL ALCOHOLS AND METHODS OF USE | F. HOFFMANN-LA ROCHE AG (CH) | 2015-02-26 | — | — | WO | disclosed |
| EP-1991530-A1 | CINNOLINE DERIVATIVES AS PHOSPHODIESTERASE 10 INHIBITORS | Amgen Inc. (US) | 2008-11-19 | — | — | EP | disclosed |
| WO-2007098169-A1 | CINNOLINE DERIVATIVES AS PHOSPHODIESTERASE 10 INHIBITORS | AMGEN INC. (US) | 2007-08-30 | — | — | WO | disclosed |