Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 6/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12937851 | 1.00 | ALDH1A1 (0.40) | ALDH1A1SMN1; SMN2LMNATSHRMEN1 | |
| SCHEMBL16706198 | 0.98 | ALDH1A1 (0.42) | ALDH1A1SMN1; SMN2LMNATSHRMEN1 | |
| SCHEMBL30956295 | 0.91 | — | — | |
| SCHEMBL27417316 | 0.91 | — | — | |
| SCHEMBL10919329 | 0.91 | — | — | |
| SCHEMBL26921074 | 0.91 | — | — | |
| SCHEMBL9611962 | 0.89 | ALDH1A1 (0.46) | ALDH1A1SMN1; SMN2LMNATSHRMEN1 | |
| SCHEMBL5541297 | 0.89 | ALDH1A1 (0.30) | ALDH1A1 | |
| SCHEMBL20462803 | 0.89 | TSHR (0.45) | ALDH1A1SMN1; SMN2LMNATSHRMEN1 | |
| SCHEMBL1002360 | 0.87 | TSHR (0.32) | LMNATSHRTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180044518-A1 | NON-REACTIVE, HYDROPHILIC POLYMERS HAVING TERMINAL SILOXANES AND METHODS FOR MAKING AND USING THE SAME | JOHNSON & JOHNSON VISION CARE (US) | 2018-02-15 | — | — | US | disclosed |
| US-9815979-B2 | Non-reactive, hydrophilic polymers having terminal siloxanes and methods for making and using the same | JOHNSON & JOHNSON VISION CARE, INC. (US) | 2017-11-14 | — | — | US | disclosed |
| US-9815979-B2 | Non-reactive, hydrophilic polymers having terminal siloxanes and methods for making and using the same | JOHNSON & JOHNSON VISION CARE, INC. (US) | 2017-11-14 | — | — | US | disclosed |
| US-20170051145-A1 | NON-REACTIVE, HYDROPHILIC POLYMERS HAVING TERMINAL SILOXANES AND METHODS FOR MAKING AND USING THE SAME | JOHNSON & JOHNSON VISION CARE (US) | 2017-02-23 | — | — | US | disclosed |
| US-20170051145-A1 | NON-REACTIVE, HYDROPHILIC POLYMERS HAVING TERMINAL SILOXANES AND METHODS FOR MAKING AND USING THE SAME | JOHNSON & JOHNSON VISION CARE (US) | 2017-02-23 | — | — | US | disclosed |
| US-9522980-B2 | Non-reactive, hydrophilic polymers having terminal siloxanes and methods for making and using the same | JOHNSON & JOHNSON VISION CARE, INC. (US) | 2016-12-20 | — | — | US | disclosed |
| US-9522980-B2 | Non-reactive, hydrophilic polymers having terminal siloxanes and methods for making and using the same | JOHNSON & JOHNSON VISION CARE, INC. (US) | 2016-12-20 | — | — | US | disclosed |
| US-9284339-B2 | Silicone compound and a use thereof | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 2016-03-15 | — | — | US | disclosed |
| US-9266985-B2 | Silicone compound and a use thereof | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 2016-02-23 | — | — | US | disclosed |
| US-20150361114-A1 | Silicone Compound and a Use Thereof | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 2015-12-17 | — | — | US | disclosed |
| US-20150133619-A1 | SILICONE COMPOUND AND A USE THEREOF | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 2015-05-14 | — | — | US | disclosed |
| US-20110275734-A1 | NON-REACTIVE, HYDROPHILIC POLYMERS HAVING TERMINAL SILOXANES AND METHODS FOR MAKING AND USING THE SAME | JOHNSON & JOHNSON VISION CARE, INC. | 2011-11-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150133619-A1 | SILICONE COMPOUND AND A USE THEREOF | STIM1, SMCHD1, SHC1 | ALDH1A1 1799/4885SMN1; SMN2 480/4885LMNA 2867/4885 |
| US-20150361114-A1 | Silicone Compound and a Use Thereof | SMCHD1, ORAI1, PITHD1 | ALDH1A1 2184/4885SMN1; SMN2 1243/4885LMNA 629/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.