Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 5/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5636821 | 0.89 | KCNH2 (0.57) | KCNH2JAK2JAK1MAP4K4 | |
| SCHEMBL4793249 | 0.89 | KCNH2 (0.51) | KCNH2 | |
| SCHEMBL4500713 | 0.89 | KCNH2 (0.51) | KCNH2 | |
| SCHEMBL2332033 | 0.83 | KCNH2 (0.41) | KCNH2 | |
| SCHEMBL4512253 | 0.82 | KCNH2 (0.49) | KCNH2 | |
| SCHEMBL4271556 | 0.82 | ATM (0.45) | KCNH2MAP4K4 | |
| SCHEMBL3113005 | 0.79 | KCNH2 (0.37) | KCNH2JAK2JAK1MAP4K4 | |
| SCHEMBL2329621 | 0.79 | KCNH2 (0.37) | KCNH2JAK2JAK1MAP4K4 | |
| SCHEMBL3111430 | 0.79 | KCNH2 (0.37) | KCNH2JAK2JAK1MAP4K4 | |
| SCHEMBL2329434 | 0.78 | KCNH2 (0.42) | KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1996579-A2 | ANTIBIOTIC COMPOUNDS | Actelion Pharmaceuticals Ltd. (CH) | 2008-12-03 | — | — | EP | disclosed |
| WO-2007105154-A2 | ANTIBIOTIC COMPOUNDS | ACTELION PHARMACEUTICALS LTD (CH) | 2007-09-20 | — | — | WO | disclosed |