Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CENPE | Q02224 | 2/20 | 0.45 |
| ▸ | GCGR | P47871 | 2/20 | 0.38 |
| ▸ | GIPR | P48546 | 2/20 | 0.38 |
| ▸ | TAS1R3 | Q7RTX0 | 4/20 | 0.37 |
| ▸ | TAS1R1 | Q7RTX1 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 5/20 | 0.36 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.36 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.35 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.35 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | PRKACA | P17612 | 1/20 | 0.35 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.35 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.35 |
| ▸ | PRKX | P51817 | 1/20 | 0.35 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.35 |
| ▸ | PRKG2 | Q13237 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2630622 | 0.94 | CENPE (0.46) | CENPETAS1R3TAS1R1ALDH1A1MAPT | |
| SCHEMBL3233585 | 0.92 | CENPE (0.41) | CENPEGCGRGIPRTAS1R3TAS1R1 | |
| SCHEMBL3223158 | 0.91 | CENPE (0.39) | CENPEGCGRGIPRTAS1R3TAS1R1 | |
| SCHEMBL3228196 | 0.89 | CENPE (0.42) | CENPEGCGRGIPRTAS1R3TAS1R1 | |
| SCHEMBL4435296 | 0.89 | CENPE (0.41) | CENPEGCGRGIPRTAS1R3TAS1R1 | |
| SCHEMBL2104300 | 0.89 | CENPE (0.55) | CENPETAS1R3TAS1R1ITGA4ITGB7 | |
| SCHEMBL2104302 | 0.89 | CENPE (0.55) | CENPETAS1R3TAS1R1ITGA4ITGB7 | |
| SCHEMBL3229991 | 0.89 | CENPE (0.45) | CENPEGCGRGIPRTAS1R3TAS1R1 | |
| SCHEMBL3229222 | 0.88 | CENPE (0.43) | CENPEGCGRGIPRTAS1R3TAS1R1 | |
| SCHEMBL3219631 | 0.88 | CENPE (0.43) | CENPEGCGRGIPRTAS1R3TAS1R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1742907-A4 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS INC (US) | 2008-01-02 | — | — | EP | disclosed |
| EP-1742907-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2007-01-17 | — | — | EP | disclosed |
| WO-2005107762-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2005-11-17 | — | — | WO | disclosed |