Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 15/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 15/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 4/20 | 0.36 |
| ▸ | AXL | P30530 | 1/20 | 0.35 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.35 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.35 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5787933 | 0.69 | AXL (0.33) | ADORA2AADORA1AXLMKNK1MKNK2 | |
| SCHEMBL25156828 | 0.68 | KDR (0.38) | ADORA2AADORA1AXLMKNK1MKNK2 | |
| SCHEMBL23716941 | 0.67 | PDK1 (0.47) | AXLMKNK1MKNK2PDPK1PARP1 | |
| SCHEMBL1874049 | 0.66 | AXL (0.34) | ADORA2AADORA1ADORA2BAXLMKNK1 | |
| SCHEMBL23716942 | 0.66 | CCNB2 (0.43) | AXLMKNK1MKNK2PDPK1PARP1 | |
| SCHEMBL4037241 | 0.64 | AXL (0.44) | ADORA2AADORA1ADORA3ADORA2BAXL | |
| SCHEMBL21393430 | 0.64 | AXL (0.44) | ADORA2AADORA1ADORA3ADORA2BAXL | |
| SCHEMBL29631094 | 0.64 | AXL (0.44) | ADORA2AADORA1ADORA3ADORA2BAXL | |
| SCHEMBL31324910 | 0.64 | AXL (0.44) | ADORA2AADORA1ADORA3ADORA2BAXL | |
| SCHEMBL29368189 | 0.64 | AXL (0.44) | ADORA2AADORA1ADORA3ADORA2BAXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2001480-A2 | INDAZOLE COMPOUNDS | Abbott Laboratories (US) | 2008-12-17 | — | — | EP | claimed |
| WO-2007117465-A2 | INDAZOLE COMPOUNDS | ABBOTT LABORATORIES (US) | 2007-10-18 | — | — | WO | claimed |
| EP-2001480-A2 | INDAZOLE COMPOUNDS | Abbott Laboratories (US) | 2008-12-17 | — | — | EP | disclosed |
| WO-2007117465-A2 | INDAZOLE COMPOUNDS | ABBOTT LABORATORIES (US) | 2007-10-18 | — | — | WO | disclosed |