Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 5/20 | 0.50 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.50 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.48 |
| ▸ | BRAF | P15056 | 1/20 | 0.45 |
| ▸ | ACKR3 | P25106 | 3/20 | 0.45 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4793943 | 0.94 | ABCB1 (0.55) | ABCB1ABCG2ACKR3TRPV1SMN1; SMN2 | |
| Trifluoroacetic Acid SCHEMBL4765215 | 0.87 | SMN1; SMN2 (0.47) | ABCB1ABCG2SLC2A1BRAFACKR3 | |
| Trifluoroacetic Acid SCHEMBL4767916 | 0.87 | TMPRSS2 (0.55) | ABCB1ABCG2SLC2A1TRPV1SMN1; SMN2 | |
| Trifluoroacetic Acid SCHEMBL4770760 | 0.84 | HRH3 (0.50) | ABCB1ABCG2SLC2A1SMN1; SMN2NPC1 | |
| Trifluoroacetic Acid SCHEMBL4765701 | 0.84 | MAPT (0.48) | ABCB1ABCG2SLC2A1ACKR3SMN1; SMN2 | |
| Trifluoroacetic Acid SCHEMBL4769820 | 0.81 | ALDH1A1 (0.46) | SLC2A1SMN1; SMN2NPC1TP53GAA | |
| Trifluoroacetic Acid SCHEMBL4774281 | 0.81 | SLC2A1 (0.58) | SLC2A1TRPV1SMN1; SMN2NPC1TP53 | |
| Trifluoroacetic Acid SCHEMBL4765533 | 0.80 | HRH3 (0.61) | SLC2A1TRPV1SMN1; SMN2NPC1TP53 | |
| Trifluoroacetic Acid SCHEMBL4768548 | 0.80 | ALDH1A1 (0.64) | SLC2A1TRPV1SMN1; SMN2NPC1TP53 | |
| Trifluoroacetic Acid SCHEMBL4774158 | 0.80 | TMPRSS2 (0.55) | ABCB1ABCG2SLC2A1ACKR3SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1713778-B1 | BENZAZEPINE DERIVATIVES AS HISTAMINE H3 ANTAGONISTS | GLAXO GROUP LTD (GB) | 2008-01-16 | — | — | EP | claimed |
| US-20070060566-A1 | Benzazepine derivatives as histamine h3 antagonists | GLAXO GROUP LIMITED (GB) | 2007-03-15 | — | — | US | claimed |
| EP-1713778-B1 | BENZAZEPINE DERIVATIVES AS HISTAMINE H3 ANTAGONISTS | GLAXO GROUP LTD (GB) | 2008-01-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070060566-A1 | Benzazepine derivatives as histamine h3 antagonists | HRH3, HRH4, HRH1 | ABCB1 1160/4885ABCG2 737/4885SLC2A1 4665/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.