Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 11/20 | 0.65 |
| ▸ | PDE5A | O76074 | 2/20 | 0.61 |
| ▸ | PDE4A | P27815 | 3/20 | 0.51 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.51 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.51 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.51 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.51 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4095293 | 0.76 | PDE5A (1.00) | PDE10APDE5APDE4APDE4BPDE4C | |
| SCHEMBL4776578 | 0.76 | PDE10A (0.48) | PDE10APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7422996 | 0.74 | PDE5A (0.61) | PDE10APDE5APDE4APDE4BPDE4C | |
| SCHEMBL7425485 | 0.74 | PDE5A (0.64) | PDE10APDE5APDE4APDE4BPDE4C | |
| SCHEMBL4794212 | 0.73 | PDE5A (0.46) | PDE10APDE5APDE4APDE4BPDE4C | |
| Bicarbonate SCHEMBL7016629 | 0.71 | PDE5A (0.57) | PDE10APDE5APDE4APDE4BPDE4C | |
| Bicarbonate SCHEMBL7017171 | 0.71 | PDE10A (0.52) | PDE10APDE5APDE4APDE4BPDE4C | |
| SCHEMBL11104154 | 0.71 | EGFR (0.53) | PDE5APDE4APDE4BPDE4CPDE4D | |
| Bicarbonate SCHEMBL7017039 | 0.70 | PDE5A (0.59) | PDE10APDE5APDE4APDE4BPDE4C | |
| SCHEMBL1609704 | 0.70 | PDE10A (0.62) | PDE10APDE5APDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008009963-A2 | PYRIMIDINE DERIVATIVES AS MODULATORS OF PARATHYROID HORMONE RECEPTORS | JAMES BLACK FOUNDATION LIMITED (GB) | 2008-01-24 | — | — | WO | disclosed |