Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 13/20 | 0.48 |
| ▸ | CHRM3 | P20309 | 5/20 | 0.35 |
| ▸ | PDE4A | P27815 | 3/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4429704 | 0.90 | PDE10A (0.59) | PDE10ACHRM3PDE4APDE4BPDE4C | |
| SCHEMBL4774460 | 0.76 | PDE10A (0.65) | PDE10ACHRM3PDE4APDE4BPDE4C | |
| SCHEMBL4421489 | 0.75 | PDE10A (0.83) | PDE10ACHRM3PDE4APDE4BPDE4C | |
| SCHEMBL909354 | 0.73 | PDE10A (0.64) | PDE10ACHRM3PDE4APDE4BPDE4C | |
| SCHEMBL4420885 | 0.73 | PDE10A (0.57) | PDE10ACHRM3PDE4APDE4BPDE4C | |
| SCHEMBL6919137 | 0.72 | PDE10A (0.40) | PDE10A | |
| SCHEMBL4419024 | 0.71 | PDE10A (0.83) | PDE10ACHRM3PDE4APDE4BPDE4C | |
| SCHEMBL6396181 | 0.71 | CHRM3 (0.43) | PDE10ACHRM3PDE4APDE4BPDE4C | |
| SCHEMBL27846371 | 0.70 | PDE10A (0.83) | PDE10ACHRM3PDE4APDE4BPDE4C | |
| SCHEMBL18520713 | 0.70 | PDE10A (0.43) | PDE10ACHRM3PDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008009963-A2 | PYRIMIDINE DERIVATIVES AS MODULATORS OF PARATHYROID HORMONE RECEPTORS | JAMES BLACK FOUNDATION LIMITED (GB) | 2008-01-24 | — | — | WO | disclosed |