Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | TACR3 | P29371 | 7/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TACR2 | P21452 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | MTOR | P42345 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | GPR88 | Q9GZN0 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31048503 | 1.00 | KMT2A (0.51) | KMT2AMEN1TACR3LMNATACR2 | |
| SCHEMBL10193852 | 0.84 | TGM2 (0.46) | KMT2AMEN1LMNATSHRALDH1A1 | |
| SCHEMBL7745702 | 0.83 | CYP2C19 (0.49) | TACR3LMNATSHRALDH1A1CYP2D6 | |
| SCHEMBL21606799 | 0.81 | KMT2A (0.49) | KMT2AMEN1TACR3LMNATACR2 | |
| SCHEMBL12880100 | 0.80 | KMT2A (0.58) | KMT2AMEN1TACR3LMNATACR2 | |
| SCHEMBL11040399 | 0.80 | KMT2A (0.58) | KMT2AMEN1TACR3LMNATACR2 | |
| SCHEMBL11784358 | 0.79 | TGM2 (0.44) | KMT2ATSHRALDH1A1CYP3A4CYP2C9 | |
| SCHEMBL14639330 | 0.78 | KMT2A (0.56) | KMT2AMEN1TACR3LMNATACR2 | |
| SCHEMBL4574038 | 0.78 | KMT2A (0.60) | KMT2AMEN1TACR3LMNATACR2 | |
| SCHEMBL25366914 | 0.77 | TACR3 (0.59) | KMT2AMEN1TACR3LMNATACR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1572678-A4 | SUBSTITUTED N-PHENYL SULFONAMIDE BRADYKININ ANTAGONISTS | ELAN PHARM INC (US) | 2008-05-07 | — | — | EP | disclosed |
| EP-1572678-A2 | SUBSTITUTED N-PHENYL SULFONAMIDE BRADYKININ ANTAGONISTS | Elan Pharmaceuticals, Inc. (US) | 2005-09-14 | — | — | EP | disclosed |
| WO-2004056319-A2 | SUBSTITUTED N-PHENYL SULFONAMIDE BRADYKININ ANTAGONISTS | ELAN PHARMACEUTICALS INC. (US) | 2004-07-08 | — | — | WO | disclosed |